Evidence map›Paper›PMID 35001662›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B.

Hyun-Wook Lee, Jill W Verlander, Gary E Shull, Autumn N Harris, I David Weiner

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 8 citations in OpenAlex.

  1. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
  2. Observational
  3. Article
  4. Lack of a role of NHE4 in renal ammonia metabolism.American journal of physiology. Renal physiology · 2025
    Article
  5. Article
  6. The astrocytic NaThe Journal of physiology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Hyun-Wook LeeDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.
Jill W VerlanderDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-4096-4897
Gary E ShullDepartment of Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati College of Medicine, Cincinnati, Ohio.
Autumn N HarrisDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-2329-3905
I David WeinerDivision of Nephrology, Hypertension, and Renal Transplantation, University of Florida College of Medicine, Gainesville, Florida.ORCID 0000-0002-0046-0600
University of Florida · USUnited States Department of Veterans Affairs · USUniversity of Cincinnati Medical Center · US

Funding

Molecular Mechanisms Regulating Ammonia MetabolismR01DK107798 · NIDDK · UNIVERSITY OF FLORIDA · PI WEINER, I. DAVID · 2016 to 2025
$3.2M
Sex Differences in Renal Ammonia MetabolismK08DK120873 · NIDDK · UNIVERSITY OF FLORIDA · PI HARRIS, AUTUMN N · 2019 to 2023
$952k
NIDDK NIH HHS K08 DK120873NIDDK NIH HHS R01 DK107798
6 · The paper itself

Abstract

The molecular mechanisms regulating ammonia metabolism are fundamental to acid-base homeostasis. Deletion of the A splice variant of Na

Indexed as

Acid-Base EquilibriumAcidosisAmmoniaAnimalsFemaleGene DeletionGenetic Predisposition to DiseaseGlutamate-Ammonia LigaseGlutaminaseHydrogen-Ion ConcentrationKidney Tubules, ProximalMaleMiceMice, Inbred C57BLMice, KnockoutPhenotypeAmmoniaGlutamate-Ammonia LigaseGlutaminasePhosphoenolpyruvate Carboxykinase (ATP)Slc4a4 protein, mouseSodium-Bicarbonate Symportersacid-baseammoniaNa+-bicarbonate cotransporter, electrogenic, isoform 1 (SLC4A4)proximal tubule

Identifiers

PMID35001662
PMCPMC8836747
OpenAlexW4205831955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.