Evidence map›Paper›PMID 35001661›Full record

ArticleAmerican journal of physiology. Renal physiology2022

Splenocyte transfer from hypertensive donors eliminates premenopausal female protection from ANG II-induced hypertension.

Megan A Sylvester, Dennis P Pollow, Caitlin Moffett, Wendy Nunez, Jennifer L Uhrlaub, Janko Nikolich-Zugich, Heddwen L Brooks

Open access · greenAbstract readComparative Study
In one paragraph

Article in American journal of physiology. Renal physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Guidelines on antibody use in physiology research.American journal of physiology. Renal physiology · 2024
    Article
  3. Review
  4. Murine Fecal Isolation and Microbiota Transplantation.Journal of visualized experiments : JoVE · 2023
    Article
  5. Cerebral arteriolar and neurovascular dysfunction after chemically induced menopause in mice.American journal of physiology. Heart and circulatory physiology · 2022
    Article
  6. Update on Immune Mechanisms in Hypertension.American journal of hypertension · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Megan A SylvesterDepartment of Physiology, University of Arizona, Tucson, Arizona.ORCID 0000-0002-6696-2734
Dennis P PollowDepartment of Physiology, University of Arizona, Tucson, Arizona.
Caitlin MoffettDepartment of Physiology, University of Arizona, Tucson, Arizona.
Wendy NunezDepartment of Physiology, University of Arizona, Tucson, Arizona.
Jennifer L UhrlaubDepartment of Immunobiology, University of Arizona, Tucson, Arizona.
Janko Nikolich-ZugichDepartment of Immunobiology, University of Arizona, Tucson, Arizona.
Heddwen L BrooksDepartment of Physiology, University of Arizona, Tucson, Arizona.
University of Arizona · US

Funding

PHYSIOLOGYT32HL007249 · NHLBI · UNIVERSITY OF ARIZONA · PI Brett A Colson, JOHN P KONHILAS · 1985 to 2026
$12.5M
T Cell-Mediated Regulation of Blood pressure In Postmenopausal HypertensionR01HL131834 · NHLBI · UNIVERSITY OF ARIZONA · PI BROOKS, HEDDWEN L · 2017 to 2020
$1.5M
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) R01HL131834HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) T32HL007249NHLBI NIH HHS R01 HL131834NHLBI NIH HHS T32 HL007249
6 · The paper itself

Abstract

Premenopausal females are protected from angiotensin II (ANG II)-induced hypertension following the adoptive transfer of T cells from normotensive donors. For the present study, we hypothesized that the transfer of hypertensive T cells (HT) or splenocytes (HS) from hypertensive donors would eliminate premenopausal protection from hypertension. Premenopausal recombination-activating gene-1 (Rag-1)

Indexed as

Adoptive TransferArterial PressureLymphocyte ActivationAge FactorsAngiotensin IIAnimalsChemokine CCL2Disease Models, AnimalEndothelin-1FemaleHomeodomain ProteinsHypertensionInflammation MediatorsMaleMiceMice, Inbred C57BLAngiotensin IICcl2 protein, mouseChemokine CCL2Endothelin-1GPER1 protein, mouseHomeodomain ProteinsInflammation MediatorsOsteopontinRAG-1 proteinReceptors, EstrogenReceptors, G-Protein-CoupledSpp1 protein, mouseTnf protein, mouseTumor Necrosis Factor-alphadendritic cellmacrophagemenopausesex differencesT cell

Identifiers

PMID35001661
PMCPMC8858666
OpenAlexW4206411107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.