Evidence map›Paper›PMID 35001654›Full record

ReviewPhysiology (Bethesda, Md.)2022

High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses.

Francisco C Villafuerte, Tatum S Simonson, Daniela Bermudez, Fabiola León-Velarde

Abstract readReview
In one paragraph

Review in Physiology (Bethesda, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Toxics · 2026
    Article
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  12. Elevated Hemoglobin Levels and Risk of ST-Segment Elevation Myocardial Infarction in High-Altitude Acute Coronary Syndrome: A Retrospective Analysis.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2026
    Article
  13. [Sex-specific hemoglobin thresholds for oxygen saturation: A non-linear regression analysis based on Tibetan inpatients].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2026
    Article
  14. Observational
  15. Altitude hypoxia and hypoxemia: pathogenesis and management.Signal transduction and targeted therapy · 2026
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Francisco C VillafuerteLaboratorio de Fisiología Comparada/Laboratorio de Fisiología del Transporte de Oxígeno, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0003-0731-8911
Tatum S SimonsonDivision of Pulmonary, Critical Care, and Sleep Medicine, School of Medicine, University of California, San Diego, La Jolla, California.ORCID 0000-0003-4062-2587
Daniela BermudezLaboratorio de Fisiología Comparada/Laboratorio de Fisiología del Transporte de Oxígeno, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0001-7879-0485
Fabiola León-VelardeLaboratorio de Fisiología Comparada/Laboratorio de Fisiología del Transporte de Oxígeno, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.ORCID 0000-0001-8398-2406

Funding

Respiratory and genomic contributions to adaptive/maladaptive hypoxia responsesR01HL145470 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2019 to 2023
$2.4M
Integrating physiology and genomics to reveal functional adaptation in high-altitK99HL118215 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2014 to 2014
$85k
NHLBI NIH HHS K99 HL118215NHLBI NIH HHS R01 HL145470Wellcome TrustWellcome Trust 107544/Z/15/Z
6 · The paper itself

Abstract

Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O

Indexed as

Altitude SicknessPolycythemiaAltitudeChronic DiseaseHumansPhenotypechronic hypoxiachronic mountain sicknessexcessive erythrocytosishigh-altitude erythrocytosis

Identifiers

PMID35001654
PMCPMC9191173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.