ArticleThe journal of physical chemistry. B2022
Effect of Water on a Hydrophobic Deep Eutectic Solvent.
Article in The journal of physical chemistry. B, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 155 citations in OpenAlex.
- Hydrophobic (deep) eutectic solvents: from characterization and modeling to rational design and applications.RSC advances · 2026Review
- Extraction and purification and microcapsulation of sea buckthorn seed proanthocyanidins using deep eutectic solvent-assisted extraction.Food chemistry: X · 2026Article
- Disruption or partitioning? Deep eutectic solvent biphasic systems for integrated seaweed biorefineries.Bioresources and bioprocessing · 2026Article
- Stoichiometry-Defined Phase Selection and Hydrophobic Molecular Sealing in Bioderived Deep Eutectic Solvents.ACS materials Au · 2026Article
- From Oilseed Waste to High-Value Bioactives: Deep Eutectic Solvents as Sustainable Refining Media.International journal of molecular sciences · 2026Review
- A Molecular Dynamics Assisted Machine Learning Investigation on Property Dependent Transitions in a Mixture of Deep Eutectic Solvent and Water.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Synthesis, spectroscopic analysis and physicochemical characterization of TOPO and lidocaine-based deep eutectic solvents with thermal stability evaluation via TGA/DTG.BMC chemistry · 2026Article
- Navigating the Solubility Landscape of APIs in Deep Eutectic Solvents: A Data-Driven Thermodynamic Taxonomy of Solvation Regimes and Mechanisms.Molecules (Basel, Switzerland) · 2026Article
- Molecular Insight into the Structural Properties of Deep Eutectic Solvents Based on Alkanolamines-A Theoretical and Experimental Study.Molecules (Basel, Switzerland) · 2026Article
- Mechanistic Insights into the Cooperative Removal of NHFoods (Basel, Switzerland) · 2026Article
- Protic Ionic Liquid-HThe journal of physical chemistry. B · 2026Article
- Water drives sequential breakdown of dynamic nanodomains in deep eutectic electrolytes.Chemical science · 2026Article
- Natural Deep Eutectic Solvents for PHB Recovery: Mechanistic Insights and Implications for Sustainable Downstream Processing.Polymers · 2026Review
- Do Dipolar Cosolvents Mitigate Microheterogeneity in Deep Eutectic Solvents? Solvation Dynamics and Solute Rotations in Glyceline/Methanol Solutions.The journal of physical chemistry. B · 2026Article
- Tailorable Antibacterial Activity and Biofilm Eradication Properties of Biocompatible α-Hydroxy Acid-Based Deep Eutectic Solvents.Pharmaceutics · 2025Article
- Eco friendly deep eutectic solvent based extraction of Raphanus sativus leaf bioactives with mechanistic and antibacterial evaluation.Scientific reports · 2025Article
- Data-Driven Classification of Solubility Space in Deep Eutectic Solvents: Deciphering Driving Forces Using PCA and K-Means Clustering.Molecules (Basel, Switzerland) · 2025Article
- Designing Ternary Chiral DES to Enhance Enantioselectivity.ACS omega · 2025Article
- Computer Vision Helps Experimentally Monitor Mixing Effects in Deep Eutectic Solvents.ACS sustainable chemistry & engineering · 2025Article
- Green NADES-Based Pretreatment Combined with Microwave-Assisted Hydrodistillation for Enhanced Fennel Essential Oil Production.Molecules (Basel, Switzerland) · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Deep eutectic solvents (DESs) formed by hydrogen bond donors and acceptors are a promising new class of solvents. Both hydrophilic and hydrophobic binary DESs readily absorb water, making them ternary mixtures, and a small water content is always inevitable under ambient conditions. We present a thorough study of a typical hydrophobic DES formed by a 1:2 mole ratio of tetrabutyl ammonium chloride and decanoic acid, focusing on the effects of a low water content caused by absorbed water vapor, using multinuclear NMR techniques, molecular modeling, and several other physicochemical techniques. Already very low water contents cause dynamic nanoscale phase segregation, reduce solvent viscosity and fragility, increase self-diffusion coefficients and conductivity, and enhance local dynamics. Water interferes with the hydrogen-bonding network between the chloride ions and carboxylic acid groups by solvating them, which enhances carboxylic acid self-correlation and ion pair formation between tetrabutyl ammonium and chloride. Simulations show that the component molar ratio can be varied, with an effect on the internal structure. The water-induced changes in the physical properties are beneficial for most prospective applications but water creates an acidic aqueous nanophase with a high halide ion concentration, which may have chemically adverse effects.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.