Evidence map›Paper›PMID 35001564›Full record

ArticlePhysiological reports2022

Nedocromil sodium and diphenhydramine HCl ameliorate exercise-induced arterial hypoxemia in highly trained athletes.

Michael A Coyle, Curtis S Goss, Wesley J Manz, Joel T Greenshields, Robert F Chapman, Joel M Stager

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05095311 (The Effect of Cetirizine HCl on Exercise-induced Arterial Hypoxemia in Highly-trained Swimmers), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05095311 phase4terminatednot on this map

The Effect of Cetirizine HCl on Exercise-induced Arterial Hypoxemia in Highly-trained Swimmers

TypeinterventionalSponsorIndiana UniversityRan2021 to 2022Enrolled16ConditionsExercise-induced Arterial HypoxemiaArmsCetirizine HCl, Placebo
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Michael A CoyleHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Curtis S GossHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.ORCID 0000-0002-9553-6603
Wesley J ManzHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Joel T GreenshieldsHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Robert F ChapmanHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Joel M StagerHH Morris Human Performance Laboratory, Department of Kinesiology, School of Public Health, Indiana University, Bloomington, Indiana, USA.
Indiana University Bloomington · USEmory University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExercise-induced arterial hypoxemia (EIAH) has been observed in highly trained endurance athletes during near maximal exercise, which may be influenced by a histamine-mediated inflammatory response at the pulmonary capillary-alveolar membrane. In order to test this hypothesis, we examined whether the mast cell stabilizer nedocromil sodium (NS) and H

methodsSeven highly trained male cross country runners (age, 21 ± 2 years; V̇O

resultsCompared to PL, there was a significant treatment effect on S

conclusionThe findings provide further evidence that histamine contributes directly or indirectly to the development of EIAH during intense exercise in highly trained athletes.

Indexed as

HypoxiaNedocromilAdultAthletesDiphenhydramineExerciseExercise TestHumansMaleOxygenOxygen ConsumptionYoung AdultDiphenhydramineNedocromilOxygenblood-gas barriergas exchangehistamineinterstitial pulmonary edema

Identifiers

PMID35001564
PMCPMC8743671
OpenAlexW4205718602

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.