ArticlePsycho-oncology2022
Risk of major depressive disorder in adolescent and young adult cancer patients in Japan.
Article in Psycho-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Perceived Social Support and Depressive Symptoms in AYA Cancer Patients: A Mediation Analysis of Hope Agency and Pathways.Children (Basel, Switzerland) · 2026Article
- Psychosomatics at the threshold: cancer, mood disorders, and the mental pain of death - where precision medicine meets spirituality.Frontiers in psychiatry · 2026Article
- Health-related conditions among long-term cancer survivors diagnosed in adolescence and young adulthood (AYA): results of the SURVAYA study.Journal of cancer survivorship : research and practice · 2025Observational
- Brain metabolic vulnerability in 18-F FDG PET/CT predict future depression risk in young cancer survivors.Translational psychiatry · 2025Observational
- The causal association between psychiatric disorders and gynecological cancer: a bidirectional Mendelian randomization study.Discover oncology · 2025Article
- Mental health disorders and determinants among adolescents living with HIV: a first national estimation in Togo (The MIND-HIV study), 2025.BMC psychiatry · 2025Article
- Impact of loneliness on depression among cancer survivors: a comparison between adolescents and young adults and other age groups.BMC cancer · 2025Article
- Patient-Reported Symptoms and Mental Health Event Risks in Adolescents and Young Adults With Cancer.Cancer medicine · 2025Article
- Clinicopathological and molecular characteristics of papillary thyroid carcinoma in adolescent and young adult patients.Endocrine journal · 2025Article
- Mortality in patients with major depressive disorder: A nationwide population-based cohort study with 11-year follow-up.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Long-term health outcomes by cancer diagnosed age among adolescent and young adult: multinational representative database.BMC medicine · 2024Article
- Nutritional status, body composition and diet quality in children with cancer.Frontiers in oncology · 2024Review
- Suicide risk among adolescents and young adults after cancer diagnosis: analysis of 34 cancer groups from 2009 to 2019.Journal of cancer survivorship : research and practice · 2023Article
- Mental health care use and related factors in adolescents and young adults with cancer.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Article
- Feasibility and preliminary effectiveness of a psychosocial support program for adolescent and young adult cancer patients in clinical practice: a retrospective observational study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023Observational
- Risk of major depressive disorder in adolescent and young adult cancer patients in Japan.Psycho-oncology · 2022Article
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3 authors.
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Abstract
objectiveTo estimate the risk of major depressive disorder (MDD) in adolescent and young adult (AYA) patients with cancer in Japan and identify risk factors for MDD among these patients.
methodsThis was a matched cohort study using a large claims database in Japan. Included patients were aged 15-39 years, newly diagnosed with cancer during 2012-2017 and assessable for a follow-up period of 12 months. Kaplan-Meier estimates and Cox proportional hazards models were used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for MDD in the AYA patients with cancer versus age-, sex- and working status-matched cancer-free controls. A subgroups analysis of the AYA patients with cancer was performed to explore MDD risk factors.
resultsA total of 3559 AYA patients with cancer and 35,590 matched controls were included in the analysis. Adolescent and young adult patients with cancer had a three-fold higher risk for MDD compared with cancer-free controls (HR, 3.12; 95% CI, 2.64-3.70). Among cancer categories with >100 patients, patients with multiple cancer categories, including those with metastatic cancer (HR, 6.73, 95% CI, 3.65-12.40) and leukemia (HR, 6.30; 95% CI, 3.75-10.58), had the greatest MDD risk versus matched controls. Patients who received inpatient chemotherapy as initial treatment had a higher risk for MDD than patients without chemotherapy (HR, 0.43; 95% CI, 0.30-0.62).
conclusionsAdolescent and young adult patients in Japan with cancer are at high risk for MDD. Particularly, those with multiple cancer categories, leukemia, and those who receive aggressive anticancer treatments should be monitored closely for symptoms of MDD.
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