ArticleJournal of magnetic resonance imaging : JMRI2022
Aortic Pulse Wave Velocity Evaluated by 4D Flow MRI Across the Adult Lifespan.
Article in Journal of magnetic resonance imaging : JMRI, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Comprehensive CMR evaluation including 4D flow-derived E/A vorticity ratio in overweight adults with and without type 2 diabetes mellitus.Cardiovascular diabetology · 2025Trial
- The Arlington study of healthy aging: a multidisciplinary community cohort study of functional decline with age.GeroScience · 2026Article
- Evaluation of Blood Flow Energy Loss before and after Endovascular Aneurysm Repair Using Four-dimensional Flow MR Imaging.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Effects of antihypertensive therapy on matrix metalloproteinase-9 levels in controlled hypertensive patients.BMC cardiovascular disorders · 2026Article
- Impaired Windkessel function and proximal aortic stiffness: Linking vascular ageing to cognitive decline.Experimental physiology · 2025Review
- Tactile-Transparent Wearable Sensor for Clinician-Friendly Pulse Wave Velocity Monitoring and Cardiovascular Risk Profiling.ACS nano · 2025Article
- 4D Flow MRI derived aortic pulse wave velocity and wall shear stress in Covid-19.Clinical imaging · 2025Article
- Peak regurgitant diastolic wall shear stress increases in bicuspid aortic valve regurgitation: association of regurgitation severities and aortic root dilation.Quantitative imaging in medicine and surgery · 2025Article
- Assessment of aortic hemodynamics in patients with thoracoabdominal aortic aneurysm using four-dimensional magnetic resonance imaging: a cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention.Nature reviews. Cardiology · 2024Review
- Article
- Revolutionizing vascular imaging: trends and future directions of 4D flow MRI based on a 20-year bibliometric analysis.Quantitative imaging in medicine and surgery · 2024Article
- Assessment of abnormal transvalvular flow and wall shear stress direction for pediatric/young adults with bicuspid aortic valve: A cross-sectional four-dimensional flow study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024Article
- Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action.Journal of the American Heart Association · 2023Review
- Characterization of aortic aging using 3D multi-parametric MRI-long-term follow-up in a population study.Scientific reports · 2023Article
- Calibration of patient-specific boundary conditions for coupled CFD models of the aorta derived from 4D Flow-MRI.Frontiers in bioengineering and biotechnology · 2023Article
- Imaging: New Frontiers in Vascular Training.Methodist DeBakey cardiovascular journal · 2022Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundEvaluation of aortic stiffness by pulse wave velocity (PWV) across the adult lifespan is needed to better understand normal aging in women and men. PURPOSE: To characterize PWV in the thoracic aorta using 4D flow MRI in an age- and sex-stratified cohort of healthy adults. STUDY TYPE: Retrospective. POPULATION: Ninety nine healthy participants (age: 46 ± 15 [19-79] years, 50% female), divided into young adults (<45 years) (N = 48), midlife (45-65 years) (N = 37), and later life (>65 years) (N = 14) groups. FIELD STRENGTH/SEQUENCE: 1.5 T or 3 T, 2D cine bSSFP, 4D flow MRI. ASSESSMENT: Cardiac functional parameters of end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV) and myocardial mass were assessed by 2D cine bSSFP. PWV and aortic blood flow velocity were assessed by 4D flow MRI. Reproducibility of PWV was evaluated in a subset of nine participants. STATISTICAL TESTS: Analysis of variance, Pearson's correlation coefficient (r), linear regression, intraclass correlation coefficient (ICC). A P value < 0.05 was considered statistically significant.
resultsPWV increased significantly with age (young adults: 5.4 ± 0.9 m/sec, midlife: 7.2 ± 1.1 m/sec, and later life: 9.4 ± 1.8 m/sec) (r = 0.79, slope = 0.09 m/sec/year). PWV did not differ in women and men in entire sample (P = 0.40) or within age groups (young adults: P = 0.83, midlife: P = 0.17, and later life: P = 0.96). PWV was significantly correlated with EDV (r = -0.29), ESV (r = -0.23), SV (r = -0.28), myocardial mass (r = 0.21), and mean aortic blood flow velocity (r = -0.62). In the test-retest subgroup (N = 9), PWV was 6.7 ± 1.5 [4.4-9.3] m/sec and ICC = 0.75. DATA
conclusion4D flow MRI quantified higher aortic PWV with age, by approximately 1 m/sec per decade, and significant differences between young adults, midlife and later life. Reproducibility analysis showed good test-retest agreement. Increased PWV was associated with decline in cardiac function and reduced aortic blood flow velocity. This study demonstrates the utility of 4D flow MRI-derived aortic PWV for studying aging. EVIDENCE LEVEL: 2 TECHNICAL EFFICACY: Stage 2.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.