Evidence map›Paper›PMID 35001440›Full record

ArticleThe European journal of neuroscience2022

Circadian transcription factor NPAS2 and the NAD

Darius D Becker-Krail, Puja K Parekh, Kyle D Ketchesin, Shintaro Yamaguchi, Jun Yoshino, Mariah A Hildebrand, Brandan Dunham, Madhavi K Ganapathiraju, Ryan W Logan, Colleen A McClung

Open access · greenAbstract read
In one paragraph

Article in The European journal of neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Darius D Becker-KrailTranslational Neuroscience Program, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0002-1751-0598
Puja K ParekhTranslational Neuroscience Program, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kyle D KetchesinTranslational Neuroscience Program, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Shintaro YamaguchiCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Jun YoshinoCenter for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA.
Mariah A HildebrandTranslational Neuroscience Program, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Brandan DunhamDepartment of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Madhavi K GanapathirajuDepartment of Biomedical Informatics, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Ryan W LoganDepartment of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.
Colleen A McClungTranslational Neuroscience Program, Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0003-4719-6197
University of Pittsburgh · USUnité de Nutrition Humaine · FRBoston University · US

Funding

Project 5: Circadian RhythmsP50DA039841 · NIDA · JACKSON LABORATORY · PI LAURA G REINHOLDT · 2016 to 2026
$26.2M
The internship in Biomedical Research, Informatics, and Computer Science (iBRIC): Biomedical Informatics and Data Science research experiences for students from Minority Serving InstitutionsT15LM007059 · NLM · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HARRY S HOCHHEISER · 1987 to 2026
$23.9M
Subject Management and BiobankingP50DA046346 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Daniel J. Buysse, Colleen A McClung · 2020 to 2026
$23.4M
Predoctorial Training in Basic NeuroscienceT32NS007433 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MERINEY, STEPHEN D · 1998 to 2022
$8.0M
Role of NPAS2 in the nucleus accumbens in drug addictionR01DA039865 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2015 to 2024
$3.9M
Generating novel mouse tools to investigate brain region and cell-type specific circadian molecular mechanisms of reward and motivationR33DA041872 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LOGAN, RYAN W · 2018 to 2020
$1.1M
Use of in vivo calcium imaging to study addiction.K02DA042886 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2017 to 2021
$602k
Impact of metabolic changes in response to chronic cocaine on circadian gene funcR21DA037636 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCCLUNG, COLLEEN A · 2014 to 2015
$420k
NIDA NIH HHS K02 DA042886NIDA NIH HHS P50 DA039841NIDA NIH HHS P50 DA046346NIDA NIH HHS R01 DA039865NIDA NIH HHS R21 DA037636NIDA NIH HHS R33 DA041872NINDS NIH HHS T32 NS007433NLM NIH HHS T15 LM007059
6 · The paper itself

Abstract

Substance use disorders are associated with disruptions to both circadian rhythms and cellular metabolic state. At the molecular level, the circadian molecular clock and cellular metabolic state may be interconnected through interactions with the nicotinamide adenine dinucleotide (NAD

Indexed as

CocaineNucleus AccumbensAnimalsBasic Helix-Loop-Helix ProteinsCircadian RhythmMiceMice, Inbred C57BLNADNerve Tissue ProteinsRewardSirtuin 1Transcription FactorsBasic Helix-Loop-Helix ProteinsCocaineNADNerve Tissue ProteinsNpas2 protein, mouseSirt1 protein, mouseSirtuin 1Transcription FactorscircadiancocaineNPAS2nucleus accumbensrewardSIRT1

Identifiers

PMID35001440
PMCPMC9355311
OpenAlexW4206726251

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.