Evidence map›Paper›PMID 35001437›Full record

Observational studyJournal of veterinary internal medicine2022

Developing a predictive model for spinal shock in dogs with spinal cord injury.

Rebecca McBride, Elizabeth Parker, Rebecca B Garabed, Natasha J Olby, Andrea Tipold, Veronika Maria Stein, Nicolas Granger, Ashley C Hechler, Page E Yaxley, Sarah A Moore and 1 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Journal of veterinary internal medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 10 institutions in 5 countries.

Rebecca McBrideDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0003-1415-6009
Elizabeth ParkerDepartment of Veterinary Preventive Medicine, The Ohio State University, Columbus, Ohio, USA.
Rebecca B GarabedDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Natasha J OlbyDepartment of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA.ORCID https://orcid.org/0000-0003-1349-3484
Andrea TipoldDepartment of Small Animal Medicine and Surgery, University of Veterinary Medicine, Hannover, Germany.ORCID https://orcid.org/0000-0002-9421-942X
Veronika Maria SteinDepartment of Clinical Veterinary Sciences, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Nicolas GrangerDepartment of Small Animal Clinical Sciences, School of Veterinary Sciences, University of Bristol, Bristol, United Kingdom.
Ashley C HechlerDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Page E YaxleyDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.
Sarah A MooreDepartment of Veterinary Clinical Sciences, The Ohio State University College of Veterinary Medicine, Columbus, Ohio, USA.ORCID https://orcid.org/0000-0002-4311-6199
CANSORT-SCI study investigators
The Ohio State University · USNorth Carolina State University · USRoyal Veterinary College · GBTexas A&M University · USUniversity of Bern · CHUniversity of Veterinary Medicine Hannover, Foundation · DEColorado State University · USLeipzig University · DEMissouri College · USPurdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReduced pelvic limb reflexes in dogs with spinal cord injury typically suggests a lesion of the L4-S3 spinal cord segments. However, pelvic limb reflexes might also be reduced in dogs with a T3-L3 myelopathy and concurrent spinal shock. HYPOTHESIS/

objectivesWe hypothesized that statistical models could be used to identify clinical variables associated with spinal shock in dogs with spinal cord injuries. ANIMALS: Cohort of 59 dogs with T3-L3 myelopathies and spinal shock and 13 dogs with L4-S3 myelopathies.

methodsData used for this study were prospectively entered by partner institutions into the International Canine Spinal Cord Injury observational registry between October 2016 and July 2019. Univariable logistic regression analyses were performed to assess the association between independent variables and the presence of spinal shock. Independent variables were selected for inclusion in a multivariable logistic regression model if they had a significant effect (P ≤ .1) on the odds of spinal shock in univariable logistic regression.

resultsThe final multivariable model included the natural log of weight (kg), the natural log of duration of clinical signs (hours), severity (paresis vs paraplegia), and pelvic limb tone (normal vs decreased/absent). The odds of spinal shock decreased with increasing weight (odds ratio [OR] = 0.28, P = .09; confidence interval [CI] 0.07-1.2), increasing duration (OR = 0.44, P = .02; CI 0.21-0.9), decreased pelvic limb tone (OR = 0.04, P = .003; CI 0.01-0.36), and increased in the presence of paraplegia (OR = 7.87, P = .04; CI 1.1-56.62). CONCLUSIONS AND CLINICAL IMPORTANCE: A formula, as developed by the present study and after external validation, could be useful for assisting clinicians in determining the likelihood of spinal shock in various clinical scenarios and aid in diagnostic planning.

Indexed as

Dog DiseasesIntervertebral Disc DisplacementSpinal Cord DiseasesSpinal Cord InjuriesAnimalsDogsHumansParaplegiaSpinal Cordfibrocartilaginous infarctherniationintervertebral disc diseaseneurologyspinal cord diseasespinal shock

Identifiers

PMID35001437
PMCPMC8965241
OpenAlexW4205206823

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.