Evidence map›Paper›PMID 35001318›Full record

ArticleBulletin of experimental biology and medicine2022

Effect of M2 Macrophage-Derived Soluble Factors on Behavioral Patterns and Cytokine Production in Various Brain Structures in Depression-Like Mice.

E V Markova, E Ya Shevela, M A Knyazeva, I V Savkin, E V Serenko, I M Rashchupkin, T G Amstislavskaya, A A Ostanin, E R Chernykh

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

E V MarkovaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E Ya ShevelaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia. shevelak@mail.ru.
M A KnyazevaResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
I V SavkinResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E V SerenkoResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
I M RashchupkinResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
T G AmstislavskayaResearch Institute of Neurosciences and Medicine, Novosibirsk, Russia.
A A OstaninResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
E R ChernykhResearch Institute of Fundamental and Clinical Immunology, Novosibirsk, Russia.
Research Institute of Fundamental and Clinical Immunology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied the effect of soluble factors derived from human macrophages polarized to M2 phenotype under conditions of serum deprivation (M2-SF) on behavioral pattern and cytokine production in various brain structures in mice with modeled stress-induced depression. Intranasal administration of M2-SF for 7 days led to stimulation of locomotor and exploratory activities and a decrease in emotional reactivity in the open-field test as well as reduction in depression-like behavior in Porsolt forced swimming test and a decrease in anxiety and anhedonia. Correction of depression-like behavior was accompanied by down-regulation of proinflammatory cytokines (IL-1β, IL-6, TNFα, and IFNγ) in pathogenetically important brain structures (striatum, hippocampus, and frontal cortex). These data indicate that the antidepressant potential of M2 type macrophages can be mediated by the anti-inflammatory effects of M2-SF.

Indexed as

Antidepressive AgentsDepressionAnimalsBrainCytokinesMacrophagesMiceAntidepressive AgentsCytokinesbehaviorcytokinesdepressionM2 macrophagesmice

Identifiers

PMID35001318
OpenAlexW4206588034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.