Evidence map›Paper›PMID 35001301›Full record

ArticleBulletin of experimental biology and medicine2022

Menthol in Combination with Iontophoresis Promotes Natamycin Penetration through the Cornea: In Vitro and In Vivo Studies.

J H Bai, X M Ding, H Y Mou, S L Wang, S H Chen

Abstract read
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In one paragraph

Article in Bulletin of experimental biology and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

J H BaiDepartment of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
X M DingDepartment of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
H Y MouDepartment of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
S L WangDepartment of Ophthalmology, Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang Province, China.
S H ChenCenter for Refractive Surgery, The Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China. baijh9422@tzzxyy.com.
Taizhou Central Hospital · CNAffiliated Eye Hospital of Wenzhou Medical College · CNTaizhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We studied whether menthol can promote penetration of natamycin, a representative antifungal macrolide agent, through the cornea. Natamycin penetration was examined using an in vitro iontophoresis system that simulates clinical scenario; menthol (0.1-0.3%, w/v) was added to the donor reservoir of a standard Franz diffusion chambers. In vivo effects of menthol on natamycin penetration were examined in a set of bioassays using rabbits inoculated with Aspergillus fumigatus in the right eye. Potential irritation to the rabbit eye was examined using a standard test. Menthol significantly (p<0.05) potentiated the effects of iontophoresis on natamycin penetration. The optimal combination seemed to be 0.2% menthol in combination with 3 mA/cm

Indexed as

KeratitisNatamycinAnimalsCorneaIontophoresisMentholRabbitsMentholNatamycinfungal keratitisiontophoresismentholnatamycinthe epithelial barrier

Identifiers

PMID35001301
OpenAlexW4205289208

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.