Evidence map›Paper›PMID 35001246›Full record

ArticleMolecular biology reports2022

Trigger of apoptosis in adenocarcinoma gastric cell line (AGS) by a complex of thiosemicarbazone and copper nanoparticles.

Mahsa Badrooh, Faezeh Shokrollahi, Shaghayegh Javan, Taraneh Ghasemipour, Samira Rezaei Mojdehi, Haniyeh Farahnak, Mahboubeh Jahani Sayyad Noveiri, Mohammad Hedayati, Ali Salehzadeh

Abstract read
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In one paragraph

Article in Molecular biology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
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  6. Frontiers in molecular biosciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Mahsa BadroohDepartment of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.ORCID http://orcid.org/0000-0003-4456-9031
Faezeh ShokrollahiDepartment of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.ORCID http://orcid.org/0000-0002-1708-8868
Shaghayegh JavanDepartment of Medical Sciences, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran.ORCID http://orcid.org/0000-0003-4735-5063
Taraneh GhasemipourDepartment of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.ORCID http://orcid.org/0000-0001-9956-3177
Samira Rezaei MojdehiDepartment of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.ORCID http://orcid.org/0000-0001-5111-7127
Haniyeh FarahnakDepartment of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran.ORCID http://orcid.org/0000-0001-8804-2835
Mahboubeh Jahani Sayyad NoveiriDepartment of Biology, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran.ORCID http://orcid.org/0000-0002-4487-547X
Mohammad HedayatiPediatric Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran.ORCID http://orcid.org/0000-0002-3477-6910
Ali SalehzadehDepartment of Biology, Rasht Branch, Islamic Azad University, Rasht, Iran. salehzadeh@iaurasht.ac.ir.ORCID http://orcid.org/0000-0003-4238-0999
Islamic Azad University Rasht Branch · IRGuilan University of Medical Sciences · IRIslamic Azad University Sari Branch · IRIslamic Azad University Tonekabon · IRUniversity of Guilan · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSeeking novel anticancer agents with minimal side effects against gastric cancer is vitally important. Copper, as an important trace element, takes roles in different physiologic pathways. Also, there is a higher demand for copper in cancer cells than normal ones. Copper complexes containing a therapeutic ligand could be promising candidates for gastric cancer chemotherapy. METHODS AND

resultsIn this work, copper oxide nanoparticles were synthesized, functionalized with glutamic acid (CuO@Glu) and conjugated with thiosemicarbazone (CuO@Glu/TSC NPs). The NPs were characterized and their antiproliferative potential against AGS cancer cells was investigated using MTT, flow cytometry, Hoechst staining, and caspase 3 activation assays. The FT-IR results showed the proper binding of TSC to CuO@Glu NPs and crystallinity of the prepared NPs was confirmed by the XRD pattern. The EDX analysis confirmed the presence of Cu, N, C, O, and S elements and lack of impurities. The Hydrodynamic size and zeta potential of the CuO@Glu/TSC NPs were 168 nm and 27.5 mV, respectively. The NPs had spherical shape and were in a size range of 10 to 60 nm in diameter. This work revealed that CuO@Glu/TSC NPs efficiently inhibited the proliferation of AGS cells with significantly lower IC

conclusionsThis study introduced CuO@Glu/TSC as an efficient anticancer against gastric cancer cells with lower toxicity toward normal cells which could be employed for cancer treatment after further studies.

Indexed as

AdenocarcinomaMetal NanoparticlesNanoparticlesThiosemicarbazonesApoptosisCopperHEK293 CellsHumansSpectroscopy, Fourier Transform InfraredCopperThiosemicarbazonesAGS cellsApoptosisCaspase-3Thiosemicarbazone

Identifiers

PMID35001246
OpenAlexW4225571502

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.