Evidence map›Paper›PMID 35001245›Full record

ArticleJournal of neuro-oncology2022

Stereotactic Laser Ablation (SLA) followed by consolidation stereotactic radiosurgery (cSRS) as treatment for brain metastasis that recurred locally after initial radiosurgery (BMRS): a multi-institutional experience.

Isabela Peña Pino, Jun Ma, Yusuke S Hori, Elena Fomchenko, Kathryn Dusenbery, Margaret Reynolds, Christopher Wilke, Jianling Yuan, Ethan Srinivasan, Matthew Grabowski and 7 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 1 country.

Isabela Peña PinoDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
Jun MaDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA.
Yusuke S HoriDepartment of Neurosurgery, The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Elena FomchenkoDepartment of Neurosurgery, Yale University School of Medicine, and Yale Cancer Center, New Haven, CT, USA.
Kathryn DusenberyDepartment of Radiation Oncology, University of Minnesota, Minneapolis, MN, USA.
Margaret ReynoldsDepartment of Radiation Oncology, University of Minnesota, Minneapolis, MN, USA.
Christopher WilkeDepartment of Radiation Oncology, University of Minnesota, Minneapolis, MN, USA.
Jianling YuanDepartment of Radiation Oncology, University of Minnesota, Minneapolis, MN, USA.
Ethan SrinivasanDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Matthew GrabowskiDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Peter FecciDepartment of Neurosurgery, Duke University Medical Center, Durham, NC, USA.
Evidio Domingo-MusibayDepartment of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, USA.
Naomi FujiokaDepartment of Medicine, Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis, MN, USA.
Gene H BarnettDepartment of Neurosurgery, The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Veronica ChangDepartment of Neurosurgery, Yale University School of Medicine, and Yale Cancer Center, New Haven, CT, USA.
Alireza M MohammadiDepartment of Neurosurgery, The Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA.
Clark C ChenDepartment of Neurosurgery, University of Minnesota, Minneapolis, MN, USA. ccchen@umn.edu.ORCID http://orcid.org/0000-0001-6258-9277
University of Minnesota · USCleveland Clinic Lerner College of Medicine · USDuke Medical Center · USYale Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe optimal treatment paradigm for brain metastasis that recurs locally after initial radiosurgery remains an area of active investigation. Here, we report outcomes for patients with BMRS treated with stereotactic laser ablation (SLA, also known as laser interstitial thermal therapy, LITT) followed by consolidation radiosurgery.

methodsClinical outcomes of 20 patients with 21 histologically confirmed BMRS treated with SLA followed by consolidation SRS and > 6 months follow-up were collected retrospectively across three participating institutions.

resultsConsolidation SRS (5 Gy × 5 or 6 Gy × 5) was carried out 16-73 days (median of 26 days) post-SLA in patients with BMRS. There were no new neurological deficits after SLA/cSRS. While 3/21 (14.3%) patients suffered temporary Karnofsky Performance Score (KPS) decline after SLA, no KPS decline was observed after cSRS. There were no 30-day mortalities or wound complications. Two patients required re-admission within 30 days of cSRS (severe headache that resolved with steroid therapy (n = 1) and new onset seizure (n = 1)). With a median follow-up of 228 days (range: 178-1367 days), the local control rate at 6 and 12 months (LC

conclusionsThis multi-institutional experience supports further investigations of SLA/cSRS as a treatment strategy for BMRS.

Indexed as

Brain NeoplasmsLaser TherapyNeoplasm Recurrence, LocalRadiosurgeryAblation TechniquesCombined Modality TherapyHumansRetrospective StudiesStereotaxic TechniquesTreatment OutcomeBrain metastasis (BM)Laser interstitial thermal therapy (LITT)Stereotactic laser ablation (SLA)Stereotactic radiosurgery (SRS)

Identifiers

PMID35001245
OpenAlexW4225986444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.