Evidence map›Paper›PMID 35001219›Full record

ArticleEuropean journal of nutrition2022

Association of soy food with cardiovascular outcomes and all-cause mortality in a Chinese population: a nationwide prospective cohort study.

Ting Xue, Junping Wen, Qin Wan, Guijun Qin, Li Yan, Guixia Wang, Yingfen Qin, Zuojie Luo, Xulei Tang, Yanan Huo and 29 more

Abstract read
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In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

39 authors.

Ting Xue *Center of Health Management, Fujian Provincial Hospital South Branch, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Junping Wen *Department of Endocrinology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
Qin WanThe Affiliated Hospital of Luzhou Medical College, Luzhou, China.
Guijun QinThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li YanSun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
Guixia WangThe First Hospital of Jilin University, Changchun, China.
Yingfen QinThe First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zuojie LuoThe First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xulei TangThe First Hospital of Lanzhou University, Lanzhou, China.
Yanan HuoJiangxi Provincial People's Hospital Affiliated to Nanchang University, Nanchang, China.
Ruying HuZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Zhen YeZhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Lixin ShiAffiliated Hospital of Guiyang Medical College, Guiyang, China.
Zhengnan GaoDalian Municipal Central Hospital, Dalian, China.
Qing SuXinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yiming MuChinese People's Liberation Army General Hospital, Beijing, China.
Jiajun ZhaoShandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
Lulu ChenUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Tianshu ZengUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Xuefeng YuTongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Qiang LiThe Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Feixia ShenThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Li ChenQilu Hospital of Shandong University, Jinan, China.
Yinfei ZhangCentral Hospital of Shanghai Jiading District, Shanghai, China.
Youmin WangThe First Affiliated Hospital of Anhui Medical University, Hefei, China.
Huacong DengThe First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chao LiuJiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing, China.
Shengli WuKaramay Municipal People's Hospital, Xinjiang, China.
Tao YangThe First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Mian LiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yu XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Min XuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tiange WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhiyun ZhaoDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jieli LuDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yufang BiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiqing WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Gang ChenDepartment of Endocrinology, Fujian Provincial Hospital, Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. chengangfj@163.com.
Guang NingDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

Chinese Medical Association Foundation and Chinese Endocrine Society 12020240314Ministry of Science and Technology of the People's Republic of China 2016YFC1304904Ministry of Science and Technology of the People's Republic of China 2016YFC1305202Ministry of Science and Technology of the People's Republic of China 2016YFC1305600Ministry of Science and Technology of the People's Republic of China 2017YFC1310700Ministry of Science and Technology of the People's Republic of China 2018YFC1311705Ministry of Science and Technology of the People's Republic of China 2018YFC1311800National Key New Drug Creation and Manufacturing Program, Ministry of Science and Technology 2012ZX09303006-001the National Key Research and Development Program of China 2016YFC0901203
6 · The paper itself

Abstract

purposeThis study aimed to clarify the association of soy intake with cardiovascular disease (CVD) and all-cause mortality.

methodsWe conducted a prospective cohort study in a Chinese population composed of 97,930 participants aged ≥ 40 years old without CVD at baseline in 2011. Habitual soy intake over a period of 12 months was evaluated using a food frequency questionnaire. All participants were classified into four groups based on their soy food consumption levels: < 15, 15-29, 30-59, and ≥ 60 g/day, with the lowest category as the reference group. Follow-up was conducted between 2014 and 2016 to assess CVD incidence and all-cause mortality since baseline, which was collected from the local mortality and disease registers of the National Disease Surveillance Point System and National Health Insurance System. The Cox proportional hazards regression models were used to analyze the relationship of soy intake with later CVD events and all-cause mortality.

resultsDuring 350,604 person-years of follow-up (median [interquartile range]: 3.16 [2.98, 4.77] years), 2523 total CVD events and 1473 all-cause mortalities were documented. After controlling for covariates, the hazard ratios (95% confidence intervals) for total CVD events across increasing soy intake levels were 1.03 (0.93-1.14); 0.96 (0.86-1.07); and 0.86 (0.75-0.98; p for trend = 0.0434), while those for all-cause mortality were 0.88 (0.77-1.02); 0.86 (0.74-1.00); and 0.83 (0.69-0.99; p for trend = 0.0084).

conclusionHigh soy intake was associated with a reduced risk of total CVD events and all-cause mortality among a Chinese population.

Indexed as

Cardiovascular DiseasesSoy FoodsAdultChinaHumansProportional Hazards ModelsProspective StudiesRisk FactorsAll-cause mortalityCardiovascular diseaseCerebral infarctionHeart failureMyocardial infarctionSoy

Identifiers

PMID35001219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.