Evidence map›Paper›PMID 35000860›Full record

ArticleJournal of diabetes and its complications2022

Type 1 diabetes and oral health: Findings from the Epidemiology of Diabetes Interventions and Complications (EDIC) study.

Larissa Steigmann, Ryan Miller, Victoria R Trapani, William V Giannobile, Barbara H Braffett, Rodica Pop-Busui, Gayle Lorenzi, William H Herman, Aruna V Sarma, Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes and its complications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Larissa SteigmannUniversity of Michigan, School of Dentistry, Department of Periodontics and Oral Medicine, Ann Arbor, MI, United States.
Ryan MillerUniversity of Maryland, School of Medicine, Division of Pediatric Endocrinology, Baltimore, MD, United States.
Victoria R TrapaniGeorge Washington University, Biostatistics Center, Rockville, MD, United States.
William V GiannobileHarvard University, School of Dental Medicine, Department of Oral Medicine, Infection, and Immunity, Boston, MA, United States.
Barbara H BraffettGeorge Washington University, Biostatistics Center, Rockville, MD, United States.
Rodica Pop-BusuiUniversity of Michigan, School of Medicine, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Ann Arbor, MI, United States.
Gayle LorenziUniversity of California, San Diego, School of Medicine, Department of Medicine, Division of Metabolism, Endocrinology and Diabetes, La Jolla, CA, United States.
William H HermanUniversity of Michigan, School of Medicine, Department of Internal Medicine, Division of Metabolism, Endocrinology and Diabetes, Ann Arbor, MI, United States; University of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, United States.
Aruna V SarmaUniversity of Michigan, School of Public Health, Department of Epidemiology, Ann Arbor, MI, United States; University of Michigan, School of Medicine, Department of Urology, Ann Arbor, MI, United States. Electronic address: asarma@umich.edu.
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
University of Michigan–Ann Arbor · USGeorge Washington University · USHarvard University · USUniversity of California, San Diego · USUniversity of Maryland, Baltimore · US

Funding

Limited Competition for the Continuation of Epidemiology of Diabetes Interventions and Complications (EDIC) Study Clinical Research Center (Collaborative U01)U01DK094157 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Ionut Bebu, Barbara Halina Braffett · 2011 to 2026
$97.6M
Epidemiology of Diabetes Interventions and Complications Data Coordinating CenterU01DK094176 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI BEBU, IONUT, BRAFFETT, BARBARA HALINA · 2012 to 2022
$30.8M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
UroEDIC Bladder: Bladder Dysfunction in Type 1 DiabetesR01DK116723 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SARMA, ARUNA V, WESSELLS, HUNTER · 2021 to 2024
$2.5M
NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK092926NIDDK NIH HHS R01 DK116723NIDDK NIH HHS U01 DK094157NIDDK NIH HHS U01 DK094176
6 · The paper itself

Abstract

objectiveTo describe long-term oral health outcomes and examine associations between sociodemographic factors, clinical characteristics, and markers of diabetes control on tooth loss in participants with type 1 diabetes enrolled in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study. RESEARCH DESIGN AND

methodsOral health outcomes related to tooth loss were reported at annual visits during EDIC years 22-26 (2015-2019). Generalized estimating equation models were used to assess the association of individual risk factors and tooth loss, over repeated time points.

resultsA total of 165 (17%) participants with type 1 diabetes reported 221 oral health outcomes related to tooth loss over a five-year period. After controlling for age and current tobacco use, the presence of diabetic peripheral neuropathy was significantly associated with an increased odds of tooth loss (OR = 1.88, 95% CI 1.24, 2.87) while higher mean HDL/LDL cholesterol ratio was significantly associated with a decreased odds of tooth loss (OR = 0.87, 95% CI = 0.79, 0.97).

conclusionsThese findings suggest that diabetes-related complications, either resulting from or independent of poor glycemia, may be directly associated with oral health conditions, and support the need for individuals with type 1 diabetes and providers to implement lifestyle and medical interventions to reduce oral health risks.

Indexed as

Diabetes ComplicationsDiabetes Mellitus, Type 1Tooth LossHumansOral HealthRisk FactorsDisease progressionOral health outcomesPeriodontitisTooth lossType 1 diabetes

Identifiers

PMID35000860
PMCPMC9241440
OpenAlexW4205899700

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.