ArticleBMC pulmonary medicine2022
Safety profile and risk factors for bleeding in transbronchial cryobiopsy using a two-scope technique for peripheral pulmonary lesions.
Article in BMC pulmonary medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07326072 (The Comparative Study of Electromagnetic Navigation Bronchoscopic With Ultra-thin Cryobiopsy and Forceps Biopsy in the Diagnosis of Peripheral Pulmonary Nodules), which is not on this map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Comparative Study of Electromagnetic Navigation Bronchoscopic With Ultra-thin Cryobiopsy and Forceps Biopsy in the Diagnosis of Peripheral Pulmonary Nodules
Who cites it
21 citing papers in PubMed.
- Comparative study of transbronchial cryobiopsy and transbronchial biopsy for diagnostic yield in peripheral pulmonary lesions.Annals of medicine · 2026Article
- Dual-scope method for hemostasis during transbronchial lung cryobiopsy: A two-patient case report.Medicine · 2026Article
- A modified cryobiopsy specimen retrieval method using a thin bronchoscope and small guide sheath for the diagnosis of peripheral pulmonary lesions.Translational lung cancer research · 2026Article
- Feasibility of direct cryobiopsy specimen retrieval through the working channel of an ultrathin bronchoscope-a retrospective study of single institute.Journal of thoracic disease · 2026Article
- Pulmonary infectious complications associated with the addition of cryobiopsy to conventional sampling for peripheral pulmonary lesions: a retrospective study.Respiratory research · 2026Observational
- Innovations in Robotic-Assisted Bronchoscopy: Current Trends and Future Prospects.Diagnostics (Basel, Switzerland) · 2026Review
- Evaluation of 1.1 mm ultrathin cryobiopsy through a guide sheath for sampling of peripheral pulmonary lesions.Journal of thoracic disease · 2025Article
- Diagnostic utility of cryobiopsy for invasive mucinous lung adenocarcinoma.Translational lung cancer research · 2025Article
- Two-Scope Technique for Tracheal Epithelial-Myoepithelial Carcinoma-A Rare Case Report and Review.Respirology case reports · 2025Article
- Fatal airway obstruction due to endobronchial bleeding post cryobiopsy: a case report.Journal of surgical case reports · 2025Article
- Safety and efficacy of transbronchial cryobiopsy for elderly lung cancer patients.BMC pulmonary medicine · 2024Article
- Diagnostic efficacy of cryobiopsy for peripheral pulmonary lesions with ground-glass opacity: a propensity score-matched analysis.Translational lung cancer research · 2024Article
- Value of ultrathin bronchoscope in improving the endobronchial ultrasound localization rate and diagnosing peripheral pulmonary nodules by cryobiopsy.BMC pulmonary medicine · 2024Article
- Modified two-scope technique for transbronchial lung cryobiopsy of peripheral pulmonary lesions.Respirology case reports · 2024Article
- Advanced Bronchoscopic Diagnostic Techniques in Lung Cancer.Tuberculosis and respiratory diseases · 2024Article
- Bronchial occlusion with endobronchial Watanabe spigots using a two-scope technique for massive haemoptysis.Respirology case reports · 2024Article
- Article
- Diagnostic Value of Transbronchial Lung Cryobiopsy Using an Ultrathin Cryoprobe and Guide Sheath for Peripheral Pulmonary Lesions.Journal of bronchology & interventional pulmonology · 2024Article
- Evaluation of deployment capability of a novel outside-the-scope, detachable catheter system for ablation of lung lesions in ex vivo human lung models.JTCVS techniques · 2022Article
- Clinical Utility of Rapid On-Site Evaluation of Touch Imprint Cytology during Cryobiopsy for Peripheral Pulmonary Lesions.Cancers · 2022Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA balloon occlusion technique is suggested for use in cryobiopsy for interstitial lung diseases because of the bleeding risk. However, it may interfere with selection of the involved bronchus for peripheral pulmonary lesions (PPLs). A two-scope technique, in which two scopes are prepared and hemostasis is started using the second scope immediately after cryobiopsy, has also been reported. This study aimed to evaluate the safety and diagnostic utility of transbronchial cryobiopsy using the two-scope technique for PPLs.
methodsData of patients who underwent conventional biopsy followed by cryobiopsy using the two-scope technique for PPLs from November 2019 to March 2021 were collected. The incidence of complications and risk factors for clinically significant bleeding (moderate to life-threatening) were investigated. Diagnostic yields were also compared among conventional biopsy, cryobiopsy, and the combination of them.
resultsA total of 139 patients were analyzed. Moderate bleeding occurred in 25 (18.0%) patients without severe/life-threatening bleeding. Although five cases required transbronchial instillation of thrombin, all bleeding was completely controlled using the two-scope technique. Other complications included two pneumothoraces and one asthmatic attack. On multivariable analysis, only ground-glass features (P < 0.001, odds ratio: 9.30) were associated with clinically significant bleeding. The diagnostic yields of conventional biopsy and cryobiopsy were 76.3% and 81.3%, respectively (P = 0.28). The total diagnostic yield was 89.9%, significantly higher than conventional biopsy alone (P < 0.001).
conclusionsThe two-scope technique provides useful hemostasis for safe cryobiopsy for PPLs, with a careful decision needed for ground-glass lesions.
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