Evidence map›Paper›PMID 35000562›Full record

ReviewGut microbes

Epigenetic regulation by gut microbiota.

Vivienne Woo, Theresa Alenghat

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 188 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
188citing papers in PubMed, 6 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

188 citing papers in PubMed, 6 syntheses or guidelines pooled it, 267 citations in OpenAlex.

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  16. PPARMolecular nutrition & food research · 2026
    Article
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  20. Gut Microbiota and Extraintestinal Cancers: Mechanistic Insights and Microbiome-Targeted Interventions.JGH open : an open access journal of gastroenterology and hepatology · 2026
    Review

128 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vivienne WooDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Theresa AlenghatDivision of Immunobiology and Center for Inflammation and Tolerance, Cincinnati Children's Hospital Medical Center and Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0003-4514-3710
Cincinnati Children's Hospital Medical Center · US

Funding

Host integration of commensal and pathogenic bacterial-derived signalsR01DK116868 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI Theresa Alenghat · 2018 to 2026
$4.1M
Epigenomic control of antimicrobial immunity in the intestineR01DK114123 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI ALENGHAT, THERESA · 2018 to 2022
$1.8M
NIDDK NIH HHS R01 DK114123NIDDK NIH HHS R01 DK116868
6 · The paper itself

Abstract

The gastrointestinal tract is continuously exposed to trillions of commensal microbes, collectively termed the microbiota, which are environmental stimuli that can direct health and disease within the host. In addition to well-established bacterial sensing pathways, microbial signals are also integrated through epigenetic modifications that calibrate the transcriptional program of host cells without altering the underlying genetic code. Microbiota-sensitive epigenetic changes include modifications to the DNA or histones, as well as regulation of non-coding RNAs. While microbiota-sensitive epigenetic mechanisms have been described in both local intestinal cells and as well in peripheral tissues, further research is required to fully decipher the complex relationship between the host and microbiota. This Review highlights current understandings of epigenetic regulation by gut microbiota and important implications of these findings in guiding therapeutic approaches to prevent or combat diseases driven by impaired microbiota-host interactions.

Indexed as

Epigenesis, GeneticGastrointestinal MicrobiomeAnimalsBacteriaGastrointestinal TractHistonesHost Microbial InteractionsHumansHistoneschromatinepigeneticsepigenomeHDAChistone modificationintestinemicrobiomeMicrobiotaSCFAs

Identifiers

PMID35000562
PMCPMC8744890
OpenAlexW4205661039

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.