Evidence map›Paper›PMID 35000467›Full record

ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2022

Gene-environment interactions increase the risk of pediatric-onset multiple sclerosis associated with ozone pollution.

Amin Ziaei, Amy M Lavery, Xiaorong Ma Shao, Cameron Adams, T Charles Casper, John Rose, Meghan Candee, Bianca Weinstock-Guttman, Greg Aaen, Yolanda Harris and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. A narrative review of genetic and environmental factors and risk for multiple sclerosis. The design of the Italian multicentric PEDIGREE study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Amin ZiaeiUniversity of California, San Francisco, San Francisco, CA, USA.
Amy M LaveryDivision of Child Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Xiaorong Ma ShaoGenetic Epidemiology and Genomics Laboratory, Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Cameron AdamsGenetic Epidemiology and Genomics Laboratory, Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
T Charles CasperThe University of Utah, Salt Lake City, UT, USA.
John RoseThe University of Utah, Salt Lake City, UT, USA.
Meghan CandeeThe University of Utah, Salt Lake City, UT, USA.
Bianca Weinstock-GuttmanBuffalo General Hospital, State University of New York at Buffalo, Buffalo, NY, USA.ORCID 0000-0001-6732-151X
Greg AaenLoma Linda University Children's Hospital, Loma Linda, CA, USA.
Yolanda HarrisThe University of Alabama, Tuscaloosa, AL, USA.
Jennifer GravesUniversity of California, San Diego, San Diego, CA, USA.
Leslie BensonPediatric Multiple Sclerosis and Related Disorders Program, Boston Children's Hospital, Boston, MA, USA.
Mark GormanPediatric Multiple Sclerosis and Related Disorders Program, Boston Children's Hospital, Boston, MA, USA.
Mary RenselCleveland Clinic, Cleveland, OH, USA.ORCID 0000-0001-9613-8394
Soe MarWashington University in St. Louis, St. Louis, MO, USA.
Tim LotzeTexas Children's Hospital, Houston, TX, USA.
Benjamin GreenbergUniversity of Texas Southwestern Medical Center, Dallas, TX, USA.
Tanuja ChitnisBrigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9897-4422
Janace HartUniversity of California, San Francisco, San Francisco, CA, USA.
Amy T WaldmanDivision of Child Neurology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Lisa F BarcellosGenetic Epidemiology and Genomics Laboratory, Divisions of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, USA.
Emmanuelle WaubantUniversity of California, San Francisco, San Francisco, CA, USA.

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Environmental and genetic risk factors for pediatric MSR01NS071463 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WAUBANT, EMMANUELLE LAURENCE · 2010 to 2015
$2.8M
NCATS NIH HHS UL1 TR002538NINDS NIH HHS R01 NS071463
6 · The paper itself

Abstract

backgroundWe previously reported a relationship between air pollutants and increased risk of pediatric-onset multiple sclerosis (POMS). Ozone is an air pollutant that may play a role in multiple sclerosis (MS) pathoetiology.

objectivesTo examine the association between county-level ozone and POMS, and the interactions between ozone pollution,

methodsCases and controls were enrolled in the Environmental and Genetic Risk Factors for Pediatric MS study of the US Network of Pediatric MS Centers. County-level-modeled ozone data were acquired from the CDC's Environmental Tracking Network. Participants were assigned ozone values based on county of residence. Values were categorized into tertiles based on healthy controls. The association between ozone tertiles and having MS was assessed by logistic regression. Interactions between tertiles of ozone level and the GG genotype of the rs928264 (G/A) single nucleotide polymorphism (SNP) within

resultsA total of 334 POMS cases and 565 controls contributed to the analyses. County-level ozone was associated with increased odds of POMS (odds ratio 2.47, 95% confidence interval (CI): 1.69-3.59 and 1.95, 95% CI: 1.32-2.88 for the upper two tertiles, respectively, compared with the lowest tertile). There was a significant additive interaction between high ozone tertiles and presence of

conclusionsIn addition to the association between high county-level ozone and POMS, we report evidence for additive interactions between higher county-level ozone and

Indexed as

B7-2 AntigenHLA-DRB1 ChainsMultiple SclerosisOzoneChildGene-Environment InteractionGenetic Predisposition to DiseaseGenotypeHumansRisk FactorsB7-2 AntigenCD86 protein, humanHLA-DRB1 ChainsOzoneCD86DRB1*15gene–environment interactionmultiple sclerosisozone pollutionPediatric onset

Identifiers

PMID35000467
PMCPMC9256753

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.