Evidence map›Paper›PMID 35000466›Full record

ArticlePerfusion2023

The interplay of inflammation and coagulation in COVID-19 Patients receiving extracorporeal membrane oxygenation support.

Akram Zaaqoq, Tariq Sallam, Caitlin Merley, Lan Anh Galloway, Sameer Desale, Jobin Varghese, Muhtadi Alnababteh, Eric Kriner, Hiroto Kitahara, Jeffrey Shupp and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Perfusion, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Observational
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Akram ZaaqoqDepartment of Critical Care Medicine, 8405MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.ORCID 0000-0003-3147-5044
Tariq SallamDepartment of Medicine, 8405MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
Caitlin MerleyDepartment of Medicine, 6572University of Pennsylvania, Philadelphia, PA, USA.
Lan Anh GallowayDepartment of Urology, 5718Vanderbilt University, Nashville, TN, USA.
Sameer Desale121577MedStar Health Research Institute, Hyattsville, MD, USA.
Jobin VargheseDepartment of Medicine, 8405MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
Muhtadi AlnababtehDepartment of Medicine, 8405MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.ORCID 0000-0001-8521-9260
Eric KrinerDepartment of Critical Care Medicine, 8405MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
Hiroto KitaharaDepartment of Cardiac Surgery, 8405MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
Jeffrey ShuppDepartment of Biochemistry and Molecular & Cellular Biology, 8405MedStar Washington Hospital Center, Georgetown University Medical Center, Washington, DC, USA.
Heidi DaltonDepartment of Pediatrics, 3313Inova Fairfax Hospital, Virginia, USA, USA.
Ezequiel MolinaDepartment of Cardiac Surgery, 8405MedStar Washington Hospital Center, Georgetown University, Washington, DC, USA.
MedStar Washington Hospital Center · USInova Fairfax Hospital · USMedStar Health · USUniversity of Pennsylvania · USVanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBleeding and thrombosis are common complications during Extracorporeal Membrane Oxygenation (ECMO) support for COVID-19 patients. We sought to examine the relationship between inflammatory status, coagulation effects, and observed bleeding and thrombosis in patients receiving venovenous (VV) ECMO for COVID-19 respiratory failure. STUDY

designCross-sectional cohort study. SETTINGS: Quaternary care institution. PATIENTS: The study period from April 1, 2020, to January 1, 2021, we included all patients with confirmed COVID-19 who received VV ECMO support.

interventionNone. MEASUREMENTS AND MAIN

resultsThirty-two patients were supported with VV ECMO during the study period, and 17 patients (53%) survived to hospital discharge. The ECMO nonsurvivors mean lactate dehydrogenase (LDH) levels were markedly elevated in comparison to survivors (1046 u/L [IQR = 509, 1305] vs 489 u/L [385 658],

conclusionThe correlation between inflammation and coagulation in the nonsurvivors supported with VV ECMO could indicate dysregulated inflammatory response and worse clinical outcomes.

Indexed as

COVID-19Extracorporeal Membrane OxygenationThrombosisCross-Sectional StudiesHemorrhageHumansInflammationRetrospective Studiesacute respiratory distress syndromeCOVID-19disseminated intravascular coagulopathyextracorporeal membrane oxygenation

Identifiers

PMID35000466
PMCPMC9931882
OpenAlexW4205848844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.