ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2022
Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- The Baboon as a Model to Study Human Health and Complex Disease.American journal of primatology · 2026Review
- Admixture influences the genetic architecture of DNA methylation in a wild primate hybrid zone.Genome biology · 2026Article
- Neurogenomic landscape associated with status-dependent cooperative behaviour.Molecular ecology · 2025Article
- Article
- Energetic costs of social dominance in wild male baboons.Proceedings. Biological sciences · 2025Article
- Beyond genes-for-behaviour: The potential for genomics to resolve long-standing questions in avian brood parasitism.Ecology and evolution · 2024Review
- A female-biased gene expression signature of dominance in cooperatively breeding meerkats.Molecular ecology · 2024Article
- DNA methylation signatures of early-life adversity are exposure-dependent in wild baboons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Spatiotemporal-social association predicts immunological similarity in rewilded mice.Science advances · 2023Article
- Age-related social selectivity: An adaptive lens on a later life social phenotype.Neuroscience and biobehavioral reviews · 2023Review
- Social and early life determinants of survival from cradle to grave: A case study in wild baboons.Neuroscience and biobehavioral reviews · 2023Review
- Mixed-species groups and the question of dominance in the social ecosystem.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- DNA methylation signatures of early life adversity are exposure-dependent in wild baboons.bioRxiv : the preprint server for biology · 2023Article
- Social association predicts immunological similarity in rewilded mice.bioRxiv : the preprint server for biology · 2023Article
- Article
- Evolutionary Approaches in Aging Research.Cold Spring Harbor perspectives in medicine · 2022Review
- Selection against admixture and gene regulatory divergence in a long-term primate field study.Science (New York, N.Y.) · 2022Article
- DomArchive: a century of published dominance data.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Distinct gene regulatory signatures of dominance rank and social bond strength in wild baboons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
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Authors and funding
13 authors at 5 institutions in 8 countries.
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Abstract
The social environment is a major determinant of morbidity, mortality and Darwinian fitness in social animals. Recent studies have begun to uncover the molecular processes associated with these relationships, but the degree to which they vary across different dimensions of the social environment remains unclear. Here, we draw on a long-term field study of wild baboons to compare the signatures of affiliative and competitive aspects of the social environment in white blood cell gene regulation, under both immune-stimulated and non-stimulated conditions. We find that the effects of dominance rank on gene expression are directionally opposite in males versus females, such that high-ranking males resemble low-ranking females, and vice versa. Among females, rank and social bond strength are both reflected in the activity of cellular metabolism and proliferation genes. However, while we observe pronounced rank-related differences in baseline immune gene activity, only bond strength predicts the fold-change response to immune (lipopolysaccharide) stimulation. Together, our results indicate that the directionality and magnitude of social effects on gene regulation depend on the aspect of the social environment under study. This heterogeneity may help explain why social environmental effects on health and longevity can also vary between measures. This article is part of the theme issue 'The centennial of the pecking order: current state and future prospects for the study of dominance hierarchies'.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.