ArticleAnnals of the New York Academy of Sciences2022
Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations.
Article in Annals of the New York Academy of Sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Calcium Supplementation in Pregnancy: A Systematic Review of Clinical Studies.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Effects of calcium supplementation on the prevention of preeclampsia: an umbrella review of systematic reviews and meta-analyses.Frontiers in medicine · 2025Pooled it
- Efficacy of a Personalized mHealth App in Improving Micronutrient Supplement Use Among Pregnant Women in Karachi, Pakistan: Parallel-Group Randomized Controlled Trial.Journal of medical Internet research · 2025Trial
- Article
- The pathophysiology of pre-eclampsia.Nature reviews. Nephrology · 2026Review
- Persistent and de novo postpartum hypertension: a scoping review of pathophysiology, evaluation, and management.NPJ cardiovascular health · 2026Article
- Calcium and zinc status and risk of preeclampsia in pregnant women with varying seafood intake in Ambon City: a case-control study.BMC research notes · 2026Observational
- Vitamin D and calcium status in HYDRIA, Greece: associations with dietary and supplemental sources.European journal of nutrition · 2026Article
- Calcium Intake and Food Sources Among Children, Adolescents and Women in Madagascar: Results from a Nationally Representative Survey.Nutrients · 2026Article
- Access and adherence to calcium supplementation among rural pregnant women and lactating mothers: findings from Chhattisgarh state of India.BMC pregnancy and childbirth · 2026Article
- Maternal calcium, phosphorus, and supplement intake before and during pregnancy and their association with preterm birth risk: based on a large cohort study.Journal of health, population, and nutrition · 2026Article
- National Adoption of World Health Organization Recommendations on Calcium Supplementation During Pregnancy.Annals of the New York Academy of Sciences · 2025Review
- Micronutrients in Obstetrics and Gynecology: Mini-Review Article.Journal of obstetrics and gynaecology of India · 2025Review
- Nutritional status and household food security of pregnant women: insights from the Nutritional Status of Expectant Mothers and their Newborn Infants (NuEMI) study in South Africa.Public health nutrition · 2025Article
- Dietary supplements and prevention of preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Review
- Progress of Eastern Mediterranean Countries towards Meeting USDA Dietary Guidelines for Pregnant Women: A Focused Review.Current nutrition reports · 2025Review
- Low adherence to aspirin and calcium carbonate for preeclampsia prevention in pregnant women with chronic hypertension in a brazilian hospital.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- The Correlation of Calcium and Hemoglobin Level Among Pregnant Women in ≥35 Weeks with the Anthropometry of Newborn Babies.International journal of women's health · 2025Article
- Low-dose calcium supplementation during pregnancy in low and middle-income countries: A cost-effectiveness analysis.PLOS global public health · 2025Article
- Association between micronutrient supplementation during pregnancy and preterm birth: evidence from a large-scale children survey and Mendelian randomization study.Frontiers in public health · 2025Article
Corrections and comments
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Authors and funding
20 authors at 15 institutions in 10 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most low- and middle-income countries present suboptimal intakes of calcium during pregnancy and high rates of mortality due to maternal hypertensive disorders. Calcium supplementation during pregnancy is known to reduce the risk of these disorders and associated complications, including preeclampsia, maternal morbidity, and preterm birth, and is, therefore, a recommended intervention for pregnant women in populations with low dietary calcium intake (e.g., where ≥25% of individuals in the population have intakes less than 800 mg calcium/day). However, this intervention is not widely implemented in part due to cost and logistical issues related to the large dose and burdensome dosing schedule (three to four 500-mg doses/day). WHO recommends 1.5-2 g/day but limited evidence suggests that less than 1 g/day may be sufficient and ongoing trials with low-dose calcium supplementation (500 mg/day) may point a path toward simplifying supplementation regimens. Calcium carbonate is likely to be the most cost-effective choice, and it is not necessary to counsel women to take calcium supplements separately from iron-containing supplements. In populations at highest risk for preeclampsia, a combination of calcium supplementation and food-based approaches, such as food fortification with calcium, may be required to improve calcium intakes before pregnancy and in early gestation.
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Registered trials
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