Evidence map›Paper›PMID 35000180›Full record

ArticleEnvironmental science and pollution research international2022

Nanoparticles for active combination radio mitigating agents of zinc coumarate and zinc caffeinate in a rat model.

Mostafa A Askar, Mona S Guida, Seham M AbuNour, Essam A Ragab, Eiman N Ali, Nadia Abdel-Magied, Nahla A Mansour, Samir A Elmasry

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mostafa A AskarDepartment of Radiation Biology Research, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Mona S GuidaGenticUnit, Pediatric Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Seham M AbuNourDepartment of Health and Radiation Research, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Essam A RagabDepartment of Natural Product Research, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Eiman N AliDepartment of Radiation Biology Research, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt.
Nadia Abdel-MagiedDepartment of Radiation Biology Research, National Centre for Radiation Research and Technology (NCRRT), Atomic Energy Authority, Cairo, Egypt. nanyabdelmagid@yahoo.com.ORCID http://orcid.org/0000-0002-9726-762X
Nahla A MansourPetrochemical Department, Egyptian Petroleum Research Institute, Nasr City, Cairo, Egypt.
Samir A ElmasryDepartment of Molecular Biology, Genetic Engineering & Biotechnology Research Institute, Sadat City, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zinc coumarate and zinc caffeinate nanoparticles (ZnCoNPs, ZnCaNPs) affect different biological processes. This study aimed to evaluate the mitigating action of ZnCoNPs in combination with ZnCaNPs against liver damage induced by gamma rays (γ-rays). Rats were exposed to 7 Gy of γ-rays and then injected intraperitoneally (i.p) with ZnCoNPs [2U/rat/day (5 mg/kg)] and ZnCaNPs [2U/rat/day (15 mg/kg)] for 7 consecutive days. The results showed that irradiated rats treated with ZnCoNPs (5 mg/kg/body weight) in combination with ZnCaNPs (15 mg/kg/body weight) for 7 days had a significant increases in body weight, antioxidant levels, T helper cell 4 (cluster of differentiation 4 (CD4)), and T cytotoxic cell 8 (cluster of differentiation 8 (CD8)), associated with a marked decrease in lipid peroxidation (LP), nitric oxide(NOx), total free radicals concentrate (TFRC), and DNA fragmentation. There were positive alterations in the morphological state, hematological parameters and the cell cycle phases. Additionally, the histopathological study demonstrated an improvement in the liver tissue of irradiated rats after treatment. Thus, ZnCoNPs and ZnCaNPs could be used as natural mitigating agents to reduce the hazards of ionizing radiation.

Indexed as

NanoparticlesRadiation-Protective AgentsAnimalsAntioxidantsBody WeightGamma RaysLipid PeroxidationOxidative StressRatsZincAntioxidantsRadiation-Protective AgentsZincAntioxidantsDNA damageNanoparticlesRadiomitigatorsRats

Identifiers

PMID35000180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.