Evidence map›Paper›PMID 35000132›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2022

Bacterial driver-passenger model in biofilms: a new mechanism in the development of colorectal cancer.

J Xing, Y Fang, W Zhang, H Zhang, D Tang, D Wang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

J XingClinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
Y FangDepartment of Clinical Medical College, Dalian Medical University, Dalian, Liaoning, People's Republic of China.
W ZhangClinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
H ZhangClinical Medical College, Yangzhou University, Yangzhou, Jiangsu Province, People's Republic of China.
D TangDepartment of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu Province Hospital, Yangzhou University, Yangzhou, 225001, People's Republic of China. 83392785@qq.com.ORCID http://orcid.org/0000-0002-2057-2968
D WangDepartment of General Surgery, Institute of General Surgery, Clinical Medical College, Northern Jiangsu Province Hospital, Yangzhou University, Yangzhou, 225001, People's Republic of China.
Yangzhou University · CNDalian Medical University · CNNorthern Jiangsu People's Hospital · CN

Funding

High-level talent six one projects top talent scientific research project of Jiangsu Province [No.LGY2019034]The Academic Science and Technology Innovation Fund for College Students [No. ×20180714]The Key disease standardization diagnosis and treatment project in Jiangsu province [BE2015664]The Social Development-Health Care Project of Yangzhou, Jiangsu Province [No. YZ2018087]The Social Development Project of Yangzhou, Jiangsu Province [No. YZ2021075]Training Project of Key Talents of Youth Medicine in Jiangsu province, China [No.QNRC2016330]
6 · The paper itself

Abstract

Colorectal cancer (CRC) is a heterogeneous disease of the intestinal epithelium and ranks the third largest diagnosed malignancy in the world. Many studies have shown that the high risk of CRC is believed to be related to the formation of biofilms. To prove causation, it will be significant to decipher which specific bacteria in biofilms initiate and maintain CRC and fully describe their underlying mechanisms. Here we introduce a bacterial driver-passenger model. This model added a novel and compelling angle to the role of microorganisms, putting more emphasis on the transformation of bacterial composition in biofilms which play different roles in the development of CRC. In this model, bacterial drivers can initiate the formation of CRC through genotoxicity, while bacterial passengers maintain the CRC process through metabolites. On the basis of these pathogens, we further turned our attention to strategies that can inhibit and eradicate these pathogenic biofilms, with the aim of finding new ways to hinder colorectal carcinogenesis.

Indexed as

Colorectal NeoplasmsGastrointestinal MicrobiomeBacteriaBiofilmsCarcinogenesisHumansBacterial driver–passenger modelBiofilmsColorectal cancerMucus

Identifiers

PMID35000132
OpenAlexW4206585557

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.