ArticleInternational journal of clinical oncology2022
Male patients with papillary thyroid cancer have a higher risk of extranodal extension.
Article in International journal of clinical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- UnexpectedAmerican journal of nuclear medicine and molecular imaging · 2024Article
- Predictors of Recurrence in Patients with Papillary Thyroid Carcinoma: Does Male Sex Matter?Cancers · 2022Article
- 2-[Diagnostics (Basel, Switzerland) · 2022Article
- Relationship of Recurrence Rate with some Characteristics in Patients with Thyroid Carcinoma.Indian journal of endocrinology and metabolismArticle
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5 authors at 2 institutions in 1 country.
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Abstract
backgroundThere is a sex disparity in papillary thyroid cancer (PTC). Male sex is associated with a higher likelihood of advanced stage disease. This study aimed to examine the significance of sex for extranodal extension (ENE) in PTC.
methodsWe reviewed the data of PTC patients who had undergone initial surgical resection from July 2012 to December 2014 (N = 1531). The effects of sex and other clinicopathological factors on ENE were investigated.
resultsOf 1531 patients identified, 377 (24.6%) were male, 816 (53.3%) had positive nodes, and 256 (16.7%) had ENE. Compared with female patients, male patients had a higher risk of ENE (P < 0.001). Multivariable analysis of clinicopathological factors revealed that male sex (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.37-2.87; P < 0.001), age older than 60 years (OR, 1.93; 95% CI, 1.08-3.35; P = 0.023), extrathyroidal extension (OR, 3.52; 95% CI, 2.42-5.14; P < 0.001), bilateral multifocality (OR, 2.18; 95% CI, 1.53-3.13; P < 0.001), and more positive nodes were significantly associated with increased risk of ENE. Patients with 6-10 positive nodes were 16.45-fold higher to have ENE than patients with 5 positive nodes or less (95% CI, 11.07-24.68; P < 0.001).
conclusionMale PTC patients had a higher risk of ENE than female. Sex was an independent predictor of ENE. The underlying mechanism needs to be investigated further.
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