ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022
Abnormal connectivity model of raphe nuclei with sensory-associated cortex in Parkinson's disease with chronic pain.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 11 citations in OpenAlex.
- Neuroimaging of the monoaminergic system in Parkinson's disease: A narrative review.Neuroimage. Reports · 2026Review
- Progress in the study of ion channel function, mechanisms, and mathematical modeling in Parkinson's disease.iScience · 2026Review
- Altered resting-state functional connectivity of raphe nucleus is associated with tremor in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Altered functional activity and connectivity in Parkinson's disease with chronic pain: a resting-state fMRI study.Frontiers in aging neuroscience · 2025Article
- Common and unique dysconnectivity profiles of dorsal and median raphe in Parkinson's disease.Human brain mapping · 2023Article
- Effectiveness and Therapeutic Mechanism of Pharmacopuncture for Pain in Parkinson's Disease: A Study Protocol for a Pilot Pragmatic Randomized, Assessor-Blinded, Usual Care-Controlled, Three-Arm Parallel Trial.International journal of environmental research and public health · 2023Article
- Periaqueductal gray connectivity in spinal cord injury-induced neuropathic pain.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
- Migraine and Tension-type Headache in Parkinson's Disease and Progressive Supranuclear Palsy/Corticobasal Syndrome.Annals of Indian Academy of NeurologyArticle
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Authors and funding
11 authors at 2 institutions in 1 country.
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Abstract
BACKGROUND AND
objectiveThere are indicates that raphe nuclei may be involved in the occurrence of chronic pain in Parkinson's disease (PD). In the study, we investigated the functional connectivity pattern of raphe nuclei in Parkinson's disease with chronic pain (PDP) to uncover its possible pathophysiology.
methodsFifteen PDP, who suffered from pain, lasted longer than 3 months, sixteen Parkinson's disease patients with no pain (nPDP) and eighteen matched normal health controls (NCs) were recruited. All subjects completed the King's Parkinson's Pain Scale (KPPS) besides Parkinson-related scale and demographics. We performed a seed-based resting-state analysis of functional magnetic resonance imaging to explore whole-brain functional connectivity of the raphe nuclei. Multiple regression model was used to explore the related factors of pain including disease duration, disease severity, Hamilton Depression Rating Scale, age, sex, levodopa equivalent dose and the strength of network functional connectivity.
resultsCompared with the nPDP, the PDP group showed stronger functional connectivity between raphe nuclei and pain-related brain regions, including parietal lobe, insular lobe, cingulum cortex and prefrontal cortex, and the functional connectivity values of those areas were significantly positively correlated with KPPS independent of the clinical variables. Compared with NCs, the combined PD groups showed decreased functional connectivity including prefrontal cortex and cingulum cortex.
conclusionsAbnormal functional connectivity model of raphe nuclei may be partly involved in pathophysiological mechanism of pain in PD.
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