ArticleClinical rheumatology2022
Mendelian randomization study on the causal effects of omega-3 fatty acids on rheumatoid arthritis.
Article in Clinical rheumatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Elucidating the Causal Relationships Between B Cells, Dendritic Cells, and Multiple Sclerosis Pathogenesis.Brain and behavior · 2026Article
- Proton pump inhibitors and the risk of urolithiasis: A Mendelian randomization study.Medicine · 2025Article
- Mendelian Randomization Analysis of the Possible Causal Relationships Between Neurodevelopment-Related Proteins and Bipolar Disorder.Brain and behavior · 2025Article
- Association between nonalcoholic fatty liver disease and bone mineral density: Mendelian randomization and mediation analysis.Bone reports · 2024Article
- Casual relationships between circulating metabolites and rheumatoid arthritis: A mendelian randomization study.Heliyon · 2024Article
- Novel insights into the complex interplay of immune dysregulation and inflammatory biomarkers in preeclampsia and fetal growth restriction: A two-step Mendelian randomization analysis.Journal of translational autoimmunity · 2024Article
- Mendelian randomisation highlights type 1 diabetes as a causal determinant of idiopathic pulmonary fibrosis.Diabetology & metabolic syndrome · 2024Article
- The causal relationship between thoracic aortic aneurysm and immune cells: a mendelian randomization study.BMC cardiovascular disorders · 2024Article
- Causal Relationships Between Emotional Instability and Respiratory Diseases: A Mendelian Randomization Analysis.Psychology research and behavior management · 2024Article
- Causal association between major depressive disorder and venous thromboembolism: a bidirectional mendelian randomization study.Frontiers in genetics · 2024Article
- Assessment of causal relationships between omega-3 and omega-6 polyunsaturated fatty acids in autoimmune rheumatic diseases: a brief research report from a Mendelian randomization study.Frontiers in nutrition · 2024Article
- The causal relationship between physical activity, sedentary time and idiopathic pulmonary fibrosis risk: a Mendelian randomization study.Respiratory research · 2023Article
- Effects of heart failure and coronary artery disease on erectile dysfunction: a two-sample mendelian randomization study.BMC urology · 2023Article
- Vitamin D and idiopathic pulmonary fibrosis: a two-sample mendelian randomization study.BMC pulmonary medicine · 2023Article
- Fatty acids and pregnancy-induced hypertension: a Mendelian randomization study.Lipids in health and disease · 2023Article
- Article
- Effects of major depression and bipolar disorder on erectile dysfunction: a two-sample mendelian randomization study.BMC medical genomics · 2023Article
- Genetic association of circulating C-reactive protein levels with idiopathic pulmonary fibrosis: a two-sample Mendelian randomization study.Respiratory research · 2023Article
- Mendelian Randomization Indicates a Causal Role for Omega-3 Fatty Acids in Inflammatory Bowel Disease.International journal of molecular sciences · 2022Article
- Mendelian randomization study on the causal effects of COVID-19 on childhood intelligence.Journal of medical virology · 2022Article
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
objectivesTo resolve the ongoing debate on the role of plasma omega-3 fatty acids in rheumatoid arthritis (RA), we attempted to identify the association between omega-3 intake and the risk of RA.
methodsWe analyzed data from the largest genome-wide association study (GWAS) for omega-3 fatty acids (N = 114,999 of European ancestry) and RA (14,361 cases and 43,923 controls of European ancestry). Mendelian randomization-egger_intercept, MR-PRESSO, and Cochran's Q test were used to determine pleiotropy and heterogeneity. Egger, weighted median, inverse variance weighted (IVW), simple mode, and weighted mode were used to evaluate the causal association of plasma omega-3 levels on RA.
resultsWe found no significant pleiotropy, heterogeneity, and bias among the omega-3 genetic instrumental variables (IVs) in RA GWAS datasets. MR analysis demonstrated that as omega-3 levels genetically increased, the risk of MS increased using MR-egger (Beta = 0.137, p = 0.037; OR = 1.146, 95% CI: [1.014, 1.296]), weighted median (Beta = 0.162, p = 0.001; OR = 1.176, 95% CI: [1.070, 1.292]), IVW (Beta = 0.102, p = 0.025; OR = 1.108, 95% CI: [1.013, 1.211]), simple mode (Beta = 0.219, p = 0.149; OR = 1.245, 95% CI: [0.931, 1.665]), and weighted mode (Beta = 0.146, p = 0.006; OR = 1.157, 95% CI: [1.051, 1.274]).
conclusionsOur analysis suggested a causal association between genetically increased plasma omega-3 levels and the increased risk of RA in populations with European ancestry. Thus, to reduce the risk of RA, those of European descent should reduce omega-3 intake. Key Points • No significant pleiotropy or heterogeneity among the omega-3 genetic IVs in RA GWAS datasets. • Genetically increased plasma omega-3 levels enhanced the risk of RA in European lineages.
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