Evidence map›Paper›PMID 34999850›Full record

ArticleInternational journal of epidemiology2022

Physical activity and risk of benign proliferative epithelial disorders of the breast, in the Women's Health Initiative.

Rita Peila, Rowan T Chlebowski, Tarah J Ballinger, Victor Kamensky, Phyllis A Richey, Nazmus Saquib, Aladdin H Shadyab, Sylvia Wassertheil-Smoller, Thomas E Rohan

Open access · bronzeAbstract read
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In one paragraph

Article in International journal of epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Rita PeilaDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York City, NY, USA.ORCID 0000-0003-1784-7921
Rowan T ChlebowskiLundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA.
Tarah J BallingerIndiana University Simon Comprehensive Center, School of Medicine, Indiana University, Indianapolis, IN, USA.
Victor KamenskyDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York City, NY, USA.
Phyllis A RicheyDepartment of Preventive Medicine, University of Tennessee Health Science Center, Memphis, TN, USA.
Nazmus SaquibDepartment of Epidemiology, College of Medicine at Sulaiman, Al Rajhi University, Saudi Arabia.
Aladdin H ShadyabHerbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla, CA, USA.
Sylvia Wassertheil-SmollerDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York City, NY, USA.
Thomas E RohanDepartment of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, New York City, NY, USA.
Albert Einstein College of Medicine · USIndiana University Indianapolis · USSulaiman Al Rajhi Colleges · SAUCLA Medical Center · USUniversity of California San Diego · USUniversity of Tennessee Health Science Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecreational physical activity (PA) has been shown to be inversely associated with breast cancer risk. However, the association of recreational PA with benign proliferative epithelial disorders (BPED) of the breast, conditions associated with increased risk of breast cancer, has not been adequately studied.

methodsWe used data from an ancillary study of benign breast disease conducted among the 68 132 postmenopausal women (aged 50-79 at recruitment) participating in the Women's Health Initiative randomized clinical trials. All clinical trial participants underwent annual or biennial mammogram screening. During the follow-up, for women who reported breast biopsies but were cancer free, the associated histological sections were obtained and subjected to standardized central pathology review. Self-reported recreational PA at baseline (n = 61 684) and at 3 years of the follow-up (n = 55 923) were quantified as metabolic equivalents [MET]-h/week. There were 1624 confirmed BPED cases during an average follow-up time of 7.7 years. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs).

resultsHigher average PA over 4 years was associated with lower risk of non-atypical BPED (P-trend = 0.02). There was a 6% lower risk of non-atypical BPED for every 5 MET-h/week increase between baseline and year 3 (HR = 0.94, 95% CI 0.89-0.99). Compared with women who remained inactive (PAbaseline and PAyear3 <9 MET-h/week), those who became active (PAbaseline<9 MET-h/week to PAyear3 ≥9 MET-h/weekee), remained active (PAbaseline and PAyear3 ≥9 MET-h/week), or decreased activity (PAbaseline ≥9 MET-h/week to PAyear3 <9 MET-h/week) had lower BPED risk.

conclusionsRecreational physical activity after menopause was associated with lower BPED risk among postmenopausal women.

Indexed as

Breast DiseasesBreast NeoplasmsAgedExerciseFemaleHumansMiddle AgedProportional Hazards ModelsRisk FactorsWomen's Healthbenign proliferative epithelial disordersbreastPhysical activitypostmenopausal women

Identifiers

PMID34999850
PMCPMC9020476
OpenAlexW3167113213

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.