Evidence map›Paper›PMID 34999843›Full record

ArticleSleep2022

Association between sleep disordered breathing in early pregnancy and glucose metabolism.

Laura Sanapo, Margaret H Bublitz, Alice Bai, Niharika Mehta, Geralyn M Messerlian, Patrick Catalano, Ghada Bourjeily

2 registry-linked trialsOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02412696 naactive not recruitingnot on this map

Placental Role in Mediating Adverse Outcomes in Obstructive Sleep Apnea

TypeinterventionalSponsorThe Miriam HospitalRan2015 to 2025Enrolled262ConditionsObstructive Sleep Apnea, Pregnancy, Obesity, PreeclampsiaArmsPositive Airway Pressure, Nasal Dilator Strips
NCT02917876 active not recruitingnot on this map

Predictors of De-novo Development of Obstructive Sleep Apnea in Pregnancy

TypeobservationalSponsorThe Miriam HospitalRan2016 to 2025Enrolled450ConditionsObstructive Sleep Apnea, Pregnancy, Obesity, Sleep
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Laura SanapoWomen's Medicine Collaborative, The Miriam Hospital, Providence, RI, USA.
Margaret H BublitzWomen's Medicine Collaborative, The Miriam Hospital, Providence, RI, USA.
Alice BaiBrown University, Providence, RI, USA.
Niharika MehtaWomen's Medicine Collaborative, The Miriam Hospital, Providence, RI, USA.
Geralyn M MesserlianDepartments of Pathology and Laboratory Medicine and Obstetrics and Gynecology, Women and Infants Hospital, Brown University, Providence, RI, USA.
Patrick CatalanoMother Infant Research Institute, Department of Obstetrics and Gynecology, Tufts University School of Medicine, Friedman School of Nutrition Science and Policy, Boston, MA, USA.ORCID 0000-0003-1276-7017
Ghada BourjeilyWomen's Medicine Collaborative, The Miriam Hospital, Providence, RI, USA.
Providence College · USBrown University · USTufts University · US

Funding

Uncoupling of IL-1 beta and VEGF-A Crosstalk Contributes to Impaired Arteriogenesis Response to Ischemia in Chronic Diabetes MellitusP20GM103652 · NIGMS · OCEAN STATE RESEARCH INSTITUTE, INC. · PI CHOUDHARY, GAURAV, HARRINGTON, ELIZABETH O · 2013 to 2022
$21.3M
Mechanisms of mindfulness training to prevent hypertensive disorders of pregnancyR01HL157288 · NHLBI · MIRIAM HOSPITAL · PI BUBLITZ, MARGARET · 2021 to 2025
$2.8M
Placental role in mediating adverse outcomes in obstructive sleep apneaR01HD078515 · NICHD · MIRIAM HOSPITAL · PI BOURJEILY, GHADA · 2014 to 2018
$2.7M
Predictors of de novo development of obstructive sleep apnea in pregnancyR01HL130702 · NHLBI · MIRIAM HOSPITAL · PI BOURJEILY, GHADA · 2016 to 2020
$2.6M
Short-Term Training Program to Increase Diversity in Health-Related ResearchR25HL088992 · NHLBI · BROWN UNIVERSITY · PI ABID, RUHUL, DIAZ, JOSEPH A · 2007 to 2024
$1.9M
NHLBI NIH HHS R01 HL130702NHLBI NIH HHS R01HL130702NHLBI NIH HHS R01 HL157288NHLBI NIH HHS R25 HL088992NICHD NIH HHS R01 HD078515NICHD NIH HHS R01HD078515NIGMS NIH HHS P20 GM103652
6 · The paper itself

Abstract

STUDY

objectivesTo examine the association between maternal sleep disordered breathing (SDB) and glucose metabolism in early gestation.

methodsWomen with body mass index (BMI) ≥27 kg/m2 and singleton pregnancies underwent in-home sleep study (HSAT) and homeostatic model assessment (HOMA) in early pregnancy. Insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were derived. Exclusion criteria included pregestational diabetes, use of continuous positive airway pressure and chronic steroid therapy. We performed linear regression analyses to evaluate the association between continuous measures of SDB (respiratory event index (REI), and oxygen desaturation index (ODI)) and glucose metabolism parameters (HOMA-IR and HOMA %B). Analyses were adjusted for a set of a priori selected variables which included gestational age, maternal age, BMI, ethnicity, race, and parity.

resultsOne hundred and ninety-two pregnant women with median (interquartile range) BMI of 35.14 (8.30) kg/m2 underwent HSAT and HOMA assessment at 11.14 (3) and 15.35 (4.14) gestational weeks, respectively. REI and ODI, as continuous values, were associated with HOMA-IR after adjusting for covariates. OSA (obstructive sleep apnea) diagnosis (REI > 5 events per hour) was not associated with HOMA-IR after adjusting for BMI (p ≥ 0.05). None of the parameters were associated with HOMA %B (p > 0.07).

conclusionsSDB and insulin resistance are associated in early pregnancy, with a dose response association between respiratory event index severity and insulin resistance. Further studies are needed to establish if pregnant women with overweight and obesity may benefit from early SDB screening to improve glucose metabolic outcome. Clinical trials: NCT02412696, Positive Airway Pressure, Sleep Apnea, and the Placenta (PAP-SAP) https://clinicaltrials.gov/ct2/show/NCT02412696?term=Bourjeily&draw=2&rank=2 and NCT02917876, Predictors of De-novo Development of Obstructive Sleep Apnea in Pregnancy (Predictors) https://clinicaltrials.gov/ct2/show/NCT02917876?term=Bourjeily&draw=2&rank=1.

Indexed as

Insulin ResistanceSleep Apnea, ObstructiveSleep Apnea SyndromesBody Mass IndexCross-Sectional StudiesFemaleGlucoseHumansObservational Studies as TopicPolysomnographyPregnancyRandomized Controlled Trials as TopicGlucose-cell functiongestational diabetesglucose metabolismHOMAinsulin resistancematernal obesitymaternal overweightmaternal sleep disordered breathingobstructive sleep apneapregnancysleep study

Identifiers

PMID34999843
PMCPMC8996028
OpenAlexW4205544593

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.