Evidence map›Paper›PMID 34999836›Full record

ArticleNeuro-oncology2022

Liquid biopsy in gliomas: A RANO review and proposals for clinical applications.

Riccardo Soffietti, Chetan Bettegowda, Ingo K Mellinghoff, Katherine E Warren, Manmeet S Ahluwalia, John F De Groot, Evanthia Galanis, Mark R Gilbert, Kurt A Jaeckle, Emilie Le Rhun and 9 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 3 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 3 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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  17. Extracellular vesicles in spine tumors: biological roles, immune modulation, and therapeutic implications.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 17 institutions in 6 countries.

Riccardo SoffiettiDivision of Neuro-Oncology, Department of Neuroscience, University and City of Health and Science Hospital, Turin, Italy.ORCID 0000-0002-9204-7038
Chetan BettegowdaDepartment of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Ingo K MellinghoffDepartment of Neurology, Memorial Sloan Kettering Cancer Center New York, USA.
Katherine E WarrenDepartment of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Manmeet S AhluwaliaBrain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, Ohio, USA.
John F De GrootDepartment of Neuro-Oncology, University of Texas, MD Anderson Cancer Center Houston, Houston, Texas, USA.
Evanthia GalanisDepartment of Radiation Oncology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-8014-786X
Mark R GilbertNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Kurt A JaeckleDepartment of Neurology, Mayo Clinic Florida, Jacksonville, Florida, USA.
Emilie Le RhunDepartments of Neurology & Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Roberta RudàDepartment of Neurology, Castelfranco Veneto/Treviso Hospital and Division of Neuro-Oncology, Department of Neuroscience, University of Turin, Turin, Italy.
Joan SeoaneVall d'Hebron Institute of Oncology (VHIO) University Hospital, Universitat Autònoma de Barcelona, ICREA,CIBERONC, Barcelona, Spain.
Niklas ThonDivision of Neuro-Oncology, Department of Neurosurgery, Ludwig Maximilians University School of Medicine, Munich, Germany.
Yoshie UmemuraDivision of Neuro-Oncology, Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Michael WellerDepartment of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1748-174X
Martin J van den BentDepartment of Neurology, Brain Tumor Center at Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Michael A VogelbaumDepartment of Neurosurgery, Cleveland Clinic, Cleveland, Ohio, USA.
Susan M ChangDivision of Neuro-Oncology, University of California San Francisco, San Francisco, California, USA.
Patrick Y WenCenter for Neuro-Oncology, Dana-Farber/Brigham and Women's Cancer Center, Harvard Medical School, Boston, Massachusetts, USA.
Cleveland Clinic · USUniversity of Zurich · CHDana-Farber Cancer Institute · USErasmus MC Cancer Institute · NLHarvard University · USJacksonville College · USJohns Hopkins University · USLudwig-Maximilians-Universität München · DEMayo Clinic · USMemorial Sloan Kettering Cancer Center · USNational Institutes of Health · USOspedale Castelfranco Veneto · ITPiedmont Reference Center for Epidemiology and Cancer Prevention · ITThe University of Texas MD Anderson Cancer Center · USUniversitat Autònoma de Barcelona · ESUniversity of California, San Francisco · USUniversity of Michigan · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Brain Tumor Clinical and Clinical Research Program (Clinical Support Services)ZIDBC011642 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OZER, BYRAM · 2015 to 2025
$23.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundThere is an extensive literature highlighting the utility of blood-based liquid biopsies in several extracranial tumors for diagnosis and monitoring.

methodsThe RANO (Response Assessment in Neuro-Oncology) group developed a multidisciplinary international Task Force to review the English literature on liquid biopsy in gliomas focusing on the most frequently used techniques, that is circulating tumor DNA, circulating tumor cells, and extracellular vesicles in blood and CSF.

resultsctDNA has a higher sensitivity and capacity to represent the spatial and temporal heterogeneity in comparison to circulating tumor cells. Exosomes have the advantages to cross an intact blood-brain barrier and carry also RNA, miRNA, and proteins. Several clinical applications of liquid biopsies are suggested: to establish a diagnosis when tissue is not available, monitor the residual disease after surgery, distinguish progression from pseudoprogression, and predict the outcome.

conclusionsThere is a need for standardization of biofluid collection, choice of an analyte, and detection strategies along with rigorous testing in future clinical trials to validate findings and enable entry into clinical practice.

Indexed as

Circulating Tumor DNAGliomaNeoplastic Cells, CirculatingBiomarkers, TumorDNA, NeoplasmHumansLiquid BiopsyBiomarkers, TumorCirculating Tumor DNADNA, Neoplasmcirculating tumor cellsCSFctDNAextracellular vesiclesgliomas

Identifiers

PMID34999836
PMCPMC9159432
OpenAlexW4205541828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.