Evidence map›Paper›PMID 34999801›Full record

ArticleInteractive cardiovascular and thoracic surgery2022

Once after a full moon: acute type A aortic dissection and lunar phases.

Henrik Bjursten, Daniel Oudin Åström, Shahab Nozohoor, Khalil Ahmad, Mariann Tang, Markus Bjurbom, Emma C Hansson, Anders Jeppsson, Christian Joost Holdflod Møller, Miko Jormalainen and 13 more

Open access · hybridAbstract read
In one paragraph

Article in Interactive cardiovascular and thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. No influence of moon phases on emergency trauma admission.Journal of orthopaedic surgery and research · 2025
    Article
  3. Article
  4. Comment on: Once after a full moon: acute type A aortic dissection and lunar phases.Interdisciplinary cardiovascular and thoracic surgery · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 11 institutions in 5 countries.

Henrik BjurstenDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.ORCID 0000-0001-5428-7455
Daniel Oudin ÅströmDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Shahab NozohoorDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Khalil AhmadDepartment of Thoracic and Cardiovascular Surgery, Aarhus University Hospital, Skejby, Denmark.
Mariann TangDepartment of Thoracic and Cardiovascular Surgery, Aarhus University Hospital, Skejby, Denmark.
Markus BjurbomDepartment of Thoracic and Cardiovascular Surgery, Karolinska University Hospital, Stockholm, Sweden.
Emma C HanssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0002-3083-0860
Anders JeppssonDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0003-2356-2295
Christian Joost Holdflod MøllerDepartment of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Miko JormalainenHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Tatu JuvonenHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.
Ari MennanderHeart Centre, Tampere University Hospital and University of Tampere, Tampere, Finland.ORCID 0000-0001-5082-4161
Peter S OlsenDepartment of Cardiothoracic Surgery, Centre for Cardiac, Vascular, Pulmonary and Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-6546-3995
Christian OlssonDepartment of Thoracic and Cardiovascular Surgery, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-5677-0747
Anders AhlssonDepartment of Thoracic and Cardiovascular Surgery, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-6913-0669
Anna OudinDivision of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden.
Emily PanDepartment of Surgery, Central Finland Central Hospital, Jyväskylä, Finland.ORCID 0000-0001-9624-6539
Peter RaivioHeart and Lung Center, Helsinki University Hospital, Helsinki, Finland.ORCID 0000-0001-6130-8242
Anders WickbomDepartment of Cardiothoracic and Vascular Surgery, Orebro University Hospital and Faculty of Medicine and Health, Orebro University, Orebro, Sweden.
Johan SjögrenDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Arnar GeirssonSection of Cardiac Surgery, Yale University School of Medicine, New Haven, CT, USA.
Tomas GudbjartssonDepartment of Cardiothoracic Surgery, Landspitali University Hospital and Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Igor ZindovicDepartment of Cardiothoracic Surgery, Lund University, Skåne University Hospital, Lund, Sweden.
Lund University · SEHelsinki University Hospital · FIKarolinska University Hospital · SEAarhus University Hospital · DKSahlgrenska University Hospital · SEUniversity of Iceland · ISCopenhagen University Hospital · DKÖrebro University Hospital · SERigshospitalet · DKTampere University Hospital · FITurku University Hospital · FI

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863Skane Regional Research
6 · The paper itself

Abstract

objectivesAcute type A aortic dissection (ATAAD) is a rare but severe condition, routinely treated with emergent cardiac surgery. Many surgeons have the notion that patients with ATAAD tend to come in clusters, but no studies have examined these observations. This investigation was undertaken to study the potential association between the lunar cycle and the incidence of ATAAD.

methodsWe collected information on 2995 patients who underwent ATAAD surgery at centres from the Nordic Consortium for Acute Type A Aortic Dissection collaboration. We cross-referenced the time of surgery with lunar phase using a case-crossover design with 2 different definitions of full moon (>99% illumination and the 7-day full moon period).

resultsThe period when the moon was illuminated the most (99% definition) did not show any significant increase in incidence for ATAAD surgery. However, when the full moon period was compared with all other moon phases, it yielded a relative risk of 1.08 [95% confidence interval (CI) 1.00-1.17, P = 0.057] and, compared to waxing moon, only the relative risk was 1.11 (95% CI 1.01-1.23, P = 0.027). The peak incidence came 4-6 days after the moon was fully illuminated.

conclusionsThis study found an overrepresentation of surgery for ATAAD during the full moon phase. The explanation for this is not known, but we speculate that sleep deprivation during full moon leads to a temporary increase in blood pressure, which in turn could trigger rupture of the aortic wall. While this finding is interesting, it needs to be corroborated and the clinical implications are debateable.

Indexed as

Aortic DissectionMoonCross-Over StudiesHumansIncidenceRetrospective StudiesRiskDissection of the aortaMoon

Identifiers

PMID34999801
PMCPMC8743114
OpenAlexW3195896176

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.