Evidence map›Paper›PMID 34999799›Full record

ArticleInteractive cardiovascular and thoracic surgery2022

Spinal cord injury during selective cerebral perfusion and segmental artery occlusion: an experimental study.

Hannu-Pekka Honkanen, Caius Mustonen, Hannu Tuominen, Kai Kiviluoma, Vesa Anttila, Tatu Juvonen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Interactive cardiovascular and thoracic surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Hannu-Pekka HonkanenDepartment of Surgery, Research Unit of Surgery, Anaesthesia and Intensive Care, University of Oulu, Medical Research Center, Oulu, Finland.ORCID 0000-0002-5861-4684
Caius MustonenDepartment of Surgery, Research Unit of Surgery, Anaesthesia and Intensive Care, University of Oulu, Medical Research Center, Oulu, Finland.
Hannu TuominenDepartment of Pathology, Oulu University Hospital, Oulu, Finland.
Kai KiviluomaDepartment of Surgery, Research Unit of Surgery, Anaesthesia and Intensive Care, University of Oulu, Medical Research Center, Oulu, Finland.ORCID 0000-0002-7480-8657
Vesa AnttilaDepartment of Surgery, Heart Center, University of Turku and Turku University Hospital, Turku, Finland.ORCID 0000-0001-7108-1141
Tatu JuvonenDepartment of Surgery, Research Unit of Surgery, Anaesthesia and Intensive Care, University of Oulu, Medical Research Center, Oulu, Finland.
University of Oulu · FIHelsinki University Hospital · FIOulu University Hospital · FIUniversity of Turku · FI

Funding

Finnish Foundation for Cardiovascular Research, Oulu University Hospital, and the Sigrid Jusélius Foundation
6 · The paper itself

Abstract

objectivesSince selective cerebral perfusion (SCP) has been used in aortic arch surgical procedures, the core temperature during lower body circulatory arrest (LBCA) has been steadily rising. Simultaneously, the use of a frozen elephant trunk (FET) graft has been increasing. The safe period of LBCA in relation to spinal cord ischaemic tolerance in combination with segmental artery occlusion by the FET procedure has not been defined.

methodsSixteen pigs were assigned to undergo 65 (n = 10) or 90 min (n = 6) of SCP at 28°C with LBCA in combination with occlusion of the 8 uppermost segmental arteries in the thoracic (Th) aorta (15-20 cm FET, Th8-level). The follow-up period consisted of a 6-h intensive period and a 5-day observation period. Near-infrared spectroscopy of the collateral network was used to determine spinal cord oxygenation. The neurological status of the patients was evaluated daily, and the brain and the spinal cord were harvested for a histopathological analysis.

resultsFive out of 6 pigs after 90 min and 1 out of 10 pigs after 65 min of LBCA died within 48 h of multiorgan failure. Of the survivors in the 65-min group, 6 out of 9 had paraparesis/paraplegia; the remaining 3 reached normal function. The lone survivor after 90 min of LBCA was paraplegic. Nadir near-infrared spectroscopy of the collateral network values at Th8 and Th10 were 34 (±5) and 39 (±4), and they were reached within 35 min of SCP in both groups.

conclusionsAn extended FET graft with LBCA and SCP durations >65 min at 28°C results in a poor outcome.

Indexed as

Aortic Aneurysm, ThoracicBlood Vessel Prosthesis ImplantationSpinal Cord InjuriesSpinal Cord IschemiaAnimalsAorta, ThoracicCerebrovascular CirculationHumansPerfusionSpinal CordSwineAortic dissectionFrozen elephant trunkSelective cerebral perfusionSpinal cord injury

Identifiers

PMID34999799
PMCPMC8923407
OpenAlexW3188088936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.