Evidence map›Paper›PMID 34999270›Full record

ArticleDrug and alcohol dependence2022

Electronic nicotine delivery systems use predicts transitions in cigarette smoking among young adults.

Alexandra Loukas, C Nathan Marti, Melissa B Harrell

Open access · greenAbstract read
In one paragraph

Article in Drug and alcohol dependence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 5 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 5 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  6. The feasibility and acceptability of Live Free From E-Cigarettes (LIFFE): A web-based vaping intervention and smoking prevention program for young adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2026
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  17. Electronic Cigarette Harms: Aggregate Evidence Shows Damage to Biological Systems.International journal of environmental research and public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Alexandra LoukasDepartment of Kinesiology & Health Education, University of Texas at Austin, 2700 San Jacinto Blvd. D3700, Austin, TX 78712, USA. Electronic address: alexandra.loukas@austin.utexas.edu.
C Nathan MartiDepartment of Kinesiology & Health Education, University of Texas at Austin, 2700 San Jacinto Blvd. D3700, Austin, TX 78712, USA.
Melissa B HarrellEpidemiology, Human Genetics, and Environmental Sciences, The University of Texas Health Science Center at Houston School of Public Health in Austin, 1616 Guadalupe Street, Suite 6.300, Austin, TX 78701, USA.
The University of Texas at Austin · USThe University of Texas Health Science Center at Houston · US

Funding

Training & Education Core p335-350P50CA180906 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI PERRY, CHERYL LEE · 2013 to 2017
$19.7M
ENDS use trajectories from adolescence through young adulthood: A longitudinal study of risk factors and profilesR01CA239097 · NCI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI HARRELL, MELISSA BLYTHE · 2019 to 2023
$3.3M
Depressive Symptoms and Tobacco Use Trajectories and Transitions across Young AdulthoodR01CA249883 · NCI · UNIVERSITY OF TEXAS AT AUSTIN · PI LOUKAS, ALEXANDRA · 2020 to 2022
$1.2M
NCI NIH HHS P50 CA180906NCI NIH HHS R01 CA239097NCI NIH HHS R01 CA249883
6 · The paper itself

Abstract

backgroundAlthough cigarette smoking during young adulthood is characterized by volatility, few studies examine if use of electronic nicotine delivery systems (ENDS) impacts transitions in cigarette use behaviors across this developmental period. The purpose of this longitudinal study was to examine the role of ENDS use on three transitions in cigarette smoking among young adults; initiation, desistance, and re-uptake.

methodsParticipants were 5029 18-29-year-olds (64.2% female) enrolled in one of 24 Texas colleges at baseline and involved in an eight-wave, 4.5-year study. A multi-state, continuous time Markov model was used to assess the role of current/past 30-day and ever ENDS use on three transitions, spanning at least six months 1) never to current smoking (initiation); 2) current to non-current smoking (desistance); and 3) non-current to current smoking (re-uptake). The model also contained time-invariant socio-demographic, and time-varying intrapersonal (other tobacco use, nicotine dependence, sensation seeking, depressive symptoms) and interpersonal (peer cigarette use) covariates.

resultsBoth current and ever ENDS use increased the probability of transitioning from never to current cigarette use (initiation) and decreased the probability of transitioning from current to non-current use (desistance). Current, but not ever, ENDS use also increased the probability of transitioning from non-current to current use (re-uptake). Adjustment for socio-demographic, intrapersonal, and interpersonal covariates did not alter these findings. DISCUSSION: ENDS use in young adulthood increases the risk for cigarette smoking behaviors across the continuum of uptake and progression. Prevention and cessation efforts targeting both ENDS and cigarette use during young adulthood are needed.

Indexed as

Cigarette SmokingElectronic Nicotine Delivery SystemsTobacco Use DisorderVapingAdultFemaleHumansLongitudinal StudiesMaleUniversitiesYoung AdultCollege studentsLongitudinal researchMarkov modelsSmokingVapingYoung adults

Identifiers

PMID34999270
PMCPMC8810737
OpenAlexW4205290766

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.