Evidence map›Paper›PMID 34999268›Full record

Trial reportDrug and alcohol dependence2022

Craving among individuals with stimulant use disorder in residential social model-based treatment - Can exercise help?

Bilal A Salem, Rachel Gonzales-Castaneda, Alfonso Ang, Richard A Rawson, Daniel Dickerson, Joy Chudzynski, Jose Penate, Brett Dolezal, Christopher B Cooper, Larissa J Mooney

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 5 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 5 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Bilal A SalemSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; London Health Sciences Center, Victoria Hospital, Western University, Schulich School of Medicine & Dentistry, Department of Psychiatry London, ON, Canada. Electronic address: bilal.salem@lhsc.on.ca.
Rachel Gonzales-CastanedaSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Psychology Department, Azusa Pacific University, CA, USA.
Alfonso AngSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Richard A RawsonSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Vermont Center for Behavior and Health, University of Vermont, USA. Electronic address: rrawson@mednet.ucla.edu.
Daniel DickersonSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Joy ChudzynskiSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Jose PenateSemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Brett DolezalExercise Physiology Research Laboratory, Division of Pulmonary Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Christopher B CooperExercise Physiology Research Laboratory, Division of Pulmonary Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Larissa J MooneySemel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Veterans Affairs Greater Los Angeles Healthcare System.
University of California, Los Angeles · USAzusa Pacific University · US

Funding

Aerobic Exercise to Improve Outcomes of Treatment for Methamphetamine DependenceR01DA027633 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAWSON, RICHARD A · 2009 to 2014
$2.7M
NIDA NIH HHS R01 DA027633
6 · The paper itself

Abstract

backgroundIn a randomized controlled 8-week trial, we examined the efficacy of aerobic and resistance exercise in reducing craving for methamphetamine (MA) among individuals with MA-use disorder during residential treatment.

methodsIndividuals with MA use disorder (138) who were newly enrolled in residential treatment volunteered for random assignment to either an 8-week exercise intervention (EX) or health education control (HE), with both conditions meeting 3 times weekly; 3 dropped out of the trial, bringing the analysis sample to 135. The majority of participants were male (80%), and 48% were Latino/Hispanic. The mean age of the sample was 31.7 (SD = 6.9) years. Using multivariate mixed models, differences between conditions were examined in: (1) craving for MA, measured by self-reported ratings on a Visual Analog Scale over the 8-week trial and, (2) MA use, measured by self-report and urine drug screens at baseline and 30 and 60 days after discharge from the 8-week study.

resultsResults revealed significantly lower craving scores among the participants in the EX group than those in the HE group over the 8-week trial (median daily craving score for EX = 13.5, for HE = 21.8; p = .009). In addition, participants with less craving during treatment had significantly lower rates of MA use after discharge than participants with high craving measured at 30-days (p = .004) and 60-days post-discharge (p < .001).

conclusionsResults support the utility of incorporating a structured exercise program for individuals with MA-use disorder to reduce craving and improve MA-use outcomes.

Indexed as

Amphetamine-Related DisordersMethamphetamineAdultAftercareCravingFemaleHumansMalePatient DischargeResidential TreatmentMethamphetamineCravingExerciseMethamphetamineOutcomes

Identifiers

PMID34999268
PMCPMC10978100
OpenAlexW4206419277

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.