SynthesisWorld neurosurgery2022
Metastases in the Pineal Region: A Systematic Review of Clinical Features, Management Strategies, and Survival Outcomes.
Synthesis in World neurosurgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- Case report of invasive lobular carcinoma with pineal metastasis.Oxford medical case reports · 2026Article
- Stereotactic radiosurgery for pineal gland metastases: results from the international radiosurgery research foundation.Journal of neuro-oncology · 2026Article
- Multimodal, Personalized Treatment of Pineal Region Tumors in Adulthood-A Single Center Study.Journal of clinical medicine · 2025Article
- Clinico-radiological Analysis and outcomes of management of pineal region space occupying lesions: A multi-departmental, retrospective case series from Pakistan.Pakistan journal of medical sciences · 2025Article
- Pituitary and pineal gland metastases from pulmonary neuroendocrine carcinoma: A case report and literature review.Molecular and clinical oncology · 2025Article
- The microsurgical infratentorial supracerebellar approach for lesions of the pineal gland: feasibility, morbidity, and functional outcomes from a single-center experience.Neurosurgical review · 2025Article
- [Neurosurgical treatment of tumors of the pineal region - literature review and overview of cases at OMIII].Magyar onkologia · 2024Review
- The role of cesium-131 brachytherapy in brain tumors: a scoping review of the literature and ongoing clinical trials.Journal of neuro-oncology · 2022Article
- Review
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundPineal region metastases are rare but often cause severe neurologic deficits. Surgical resection and chemoradiotherapy can provide therapeutic benefit. We investigated the literature to analyze clinical characteristics, management strategies, and survival of adult patients with pineal region metastases.
methodsPubMed, Embase, Scopus, and Cochrane were searched following the PRISMA guidelines, including studies reporting clinical outcomes of patients with pineal region metastases. Clinical presentation, management, and survival were reviewed.
resultsWe included 31 studies comprising 47 patients. Lung cancer (29.8%) and carcinomas of unknown origin (14.9%) were the most frequent primary tumors. In 48.9% of patients, symptomatic pineal metastases preceded primary tumor diagnosis. Headache (67.4%) and confusion (46.5%) were the most common symptoms. Parinaud syndrome (46.5%) and hydrocephalus (87.2%) were noted. Biopsy (65.9%) was preferred over resection (34.1%), and shunting strategies used were endoscopic third ventriculostomy (43.9%) and ventriculoperitoneal (26.8%). Eleven patients (32.3%) received adjuvant chemotherapy and 32 (68%) received radiotherapy. Posttreatment improvement in symptoms (56.6%) and hydrocephalus (80.5%) were noted. In patients who received adjuvant chemotherapy/radiotherapy, significant improvement in posttreatment performance status occurred with both biopsy (P < 0.001) and resection (P = 0.007). No survival differences were reported between surgery and biopsy (P = 0.912) or between complete and partial resection (P = 0.220). Overall survival was neither influenced by surgical approach (P = 0.157) nor by shunting strategy (P = 0.822). Mean follow-up was 8 months and median overall survival 3 months. Only 2 cases (4.8%) of pineal metastasis showed recurrence.
conclusionsPineal region metastases carry significant morbidity. Biopsy or surgical resection, combined with adjuvant chemotherapy/radiotherapy and/or shunting, may significantly improve performance status.
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