ArticleBone2022
Modulating the systemic and local adaptive immune response after fracture improves bone regeneration during aging.
Article in Bone, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- War, what is it good for? orthopedics the evolution of orthopedic surgery through armed conflict.Bulletin of the Hospital for Joint Disease (2013) · 2026Review
- Role of the immune microenvironment in bone regeneration and progress in immune-modulating bone nanobiomaterials.Journal of Zhejiang University. Science. B · 2026Review
- Engineered and decellularized human cartilage graft exhibits intrinsic immunosuppressive properties and full skeletal repair capacity.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Challenges and Countermeasures for Ensuring Health and Drug Stability During Long-term Space Missions.Current drug discovery technologies · 2026Review
- Review
- Calcium Phosphates for Bone Tissue Regeneration-Influence of Synthesis Method on Physicochemical and Biological Properties.Materials (Basel, Switzerland) · 2025Article
- Article
- Age-related alterations of angiogenesis, inflammation and bone microarchitecture during fracture healing in mice.GeroScience · 2025Article
- Load-bearing aerobic exercise prior to injury moderates systemic immunosuppression response to fracture.Frontiers in physiology · 2025Article
- Article
- Immunoengineering Biomaterials for Musculoskeletal Tissue Repair across Lifespan.Advanced materials (Deerfield Beach, Fla.) · 2024Review
- Osteoimmunology of Fracture Healing.Current osteoporosis reports · 2024Review
- The local and systemic effects of immune function on fracture healing.OTA international : the open access journal of orthopaedic trauma · 2024Review
- Biomimetic Therapeutics for Bone Regeneration: A Perspective on Antiaging Strategies.Macromolecular bioscience · 2024Review
- Temporal dynamics of immune-stromal cell interactions in fracture healing.Frontiers in immunology · 2024Review
- Inflammatory Processes Affecting Bone Health and Repair.Current osteoporosis reports · 2023Review
- Bone regeneration in inflammation with aging and cell-based immunomodulatory therapy.Inflammation and regeneration · 2023Review
- Radiographic, Biomechanical and Histological Characterization of Femoral Fracture Healing in Aged CD-1 Mice.Bioengineering (Basel, Switzerland) · 2023Article
- The role of macrophages in fracture healing: a narrative review of the recent updates and therapeutic perspectives.Stem cell investigation · 2023Review
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Tissue injury leads to the well-orchestrated mobilization of systemic and local innate and adaptive immune cells. During aging, immune cell recruitment is dysregulated, resulting in an aberrant inflammatory response that is detrimental for successful healing. Here, we precisely define the systemic and local immune cell response after femur fracture in young and aging mice and identify increased toll-like receptor signaling as a potential culprit for the abnormal immune cell recruitment observed in aging animals. Myd88, an upstream regulator of TLR-signaling lies at the core of this aging phenotype, and local treatment of femur fractures with a Myd88 antagonist in middle-aged mice reverses the aging phenotype of impaired fracture healing, thus offering a promising therapeutic target that could overcome the negative impact of aging on bone regeneration.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.