Evidence map›Paper›PMID 34998971›Full record

ArticleNeuroImage2022

Lower resting brain entropy is associated with stronger task activation and deactivation.

Liandong Lin, Da Chang, Donghui Song, Yiran Li, Ze Wang

Abstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Brain Entropy: Linking Brain Structure to Task Activation.bioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. [Research on the relationship between resting-state spontaneous electroencephalography and task-evoked electroencephalography].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
  8. The effects of intermittent theta burst stimulation (iTBS) on resting-state brain entropy (BEN).Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Task-induced changes in brain entropy.Journal of neuroscience research · 2024
    Article
  14. The brain entropy dynamics in resting state.Frontiers in neuroscience · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Task-induced changes in brain entropy.medRxiv : the preprint server for health sciences · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liandong LinCollege of Electronic Engineering, Heilongjiang University, Harbin 150080, China.
Da ChangState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
Donghui SongState Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing 100875, China.
Yiran LiDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 670 W Baltimore St, Room 1173, Baltimore, MD 21201, United States.
Ze WangDepartment of Diagnostic Radiology and Nuclear Medicine, University of Maryland School of Medicine, 670 W Baltimore St, Room 1173, Baltimore, MD 21201, United States. Electronic address: Ze.Wang@som.umaryland.edu.

Funding

QAQC Johns Hopkins Institute for Clinical and Translational ResearchUL1TR003098 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2019 to 2023
$57.7M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
Diversity Supplement to Brain entropy mapping in Alzheimer's DiseaseR01AG070227 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, ZE · 2021 to 2024
$2.5M
Assessing ASL CBF as a biomarker for early Alzheimer's disease detection and disease progressionR01AG060054 · NIA · UNIVERSITY OF MARYLAND BALTIMORE · PI WANG, ZE · 2019 to 2021
$1.7M
High Spectral/Spatial Resolution Imaging Breast CancerR01EB003108 · NIBIB · UNIVERSITY OF CHICAGO · PI KARCZMAR, GREGORY S · 2003 to 2006
$1.2M
NCATS NIH HHS UL1 TR003098NIA NIH HHS R01 AG060054NIA NIH HHS R01 AG070227NIBIB NIH HHS P41 EB029460NIBIB NIH HHS R01 EB003108NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Brain entropy (BEN) calculated from resting state fMRI has been the subject of increasing research interest in recent years. Previous studies have shown the correlations between rest BEN and neurocognition and task performance, but how this relates to task-evoked brain activations and deactivations remains unknown. The purpose of this study is to address this open question using large data (n = 862). Voxel wise correlations were calculated between rest BEN and task activations/deactivations of five different tasks. For most of the assessed tasks, lower rest BEN was found to be associated with stronger activations (negative correlations) and stronger deactivations (positive correlations) only in brain regions activated or deactivated by the tasks. Higher workload evoked spatially more extended negative correlations between rest BEN and task activations. These results not only confirm that resting brain activity can predict brain activity during task performance but also for the first time show that resting brain activity may facilitate both task activations and deactivations. In addition, the results provide a clue to understanding the individual differences of task performance and brain activations.

Indexed as

Brain MappingAdultBiological Variation, PopulationBrainEntropyHumansMagnetic Resonance ImagingPsychomotor PerformanceRestBENtbxEntropyfMRIResting state fMRITaskTask activationTask deactivation

Identifiers

PMID34998971
PMCPMC8881863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.