Observational studyClinica chimica acta; international journal of clinical chemistry2022
The ratio of cardiac troponin T to troponin I may indicate non-necrotic troponin release among COVID-19 patients.
Observational study in Clinica chimica acta; international journal of clinical chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Cardiac troponin patterns in athletes completing Norseman Xtreme Triathlon.BMJ open sport & exercise medicine · 2026Article
- The clinical characteristics analysis of serum markers for the cardiovascular system in early-stage COVID-19 patients.Frontiers in cardiovascular medicine · 2024Article
- Cardiac troponin release following coronary artery bypass grafting: mechanisms and clinical implications.European heart journal · 2023Review
- Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?Journal of clinical medicine · 2022Article
- Article
- Mild COVID-19 induces early, quantifiable, persistent troponin I elevations in elder men.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
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Abstract
backgroundAlthough cardiac troponin T (cTnT) and troponin I(cTnI) are expressed to similar amount in cardiac tissue, cTnI often reach ten-times higher peak levels compared to cTnT in patients with myocardial necrosis such as in acute myocardial infarction (MI). In contrast, similar levels of cTnT and cTnI are observed in other situations such as stable atrial fibrillation and after strenuous exercise.
objectiveExamine cTnT and cTnI levels in relation to COVID-19 disease and MI.
methodsClinical and laboratory data from the local hospital from an observational cohort study of 27 patients admitted with COVID-19 and 15 patients with myocardial infarction (MI) that were analyzed with paired cTnT and cTnI measurement during hospital care.
resultsLevels of cTnI were lower than cTnT in COVID-19 patients (TnI/TnT ratio 0.3, IQR: 0.1-0.6). In contrast, levels of cTnI were 11 times higher compared to cTnT in 15 patients with MI (TnI/TnT ratio 11, IQR: 7-14). The peak cTnI/cTnT ratio among the patients with MI following successful percutaneous intervention were 14 (TnI/TnT ratio 14, IQR: 12-23). The 5 COVID-19 patient samples collected under possible necrotic events had a cTnI/cTnT ratio of 5,5 (IQR: 1,9-8,3).
conclusionsIn patients with COVID-19, cTnT is often elevated to higher levels than cTnI in sharp contrast to patients with MI, indicating that the release of cardiac troponin has a different cause in COVID-19 patients.
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