Evidence map›Paper›PMID 34998712›Full record

ArticleArchives of physical medicine and rehabilitation2022

Cerebellar Contributions to Motor and Cognitive Control in Multiple Sclerosis

Nora E Fritz, Erin M Edwards, Chuyang Ye, Jerry Prince, Zhen Yang, Timothy Gressett, Jennifer Keller, Emily Myers, Peter A Calabresi, Kathleen M Zackowski

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of physical medicine and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Nora E FritzCenter for Movement Studies, Kennedy Krieger Institute, Baltimore, MD; Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD; Department of Health Care Sciences, Wayne State University, Detroit, MI; Department of Neurology, Wayne State University, Detroit, MI; Translational Neuroscience Program, Wayne State University, Detroit, MI. Electronic address: Nora.fritz@wayne.edu.
Erin M EdwardsDepartment of Health Care Sciences, Wayne State University, Detroit, MI; Translational Neuroscience Program, Wayne State University, Detroit, MI.
Chuyang YeSchool of Information and Electronics, Beijing Institute of Technology, Beijing, China.
Jerry PrinceElectrical and Computer Engineering, Johns Hopkins University, Baltimore, MD.
Zhen YangElectrical and Computer Engineering, Johns Hopkins University, Baltimore, MD.
Timothy GressettSchool of Medicine, Tulane University, New Orleans, LA.
Jennifer KellerCenter for Movement Studies, Kennedy Krieger Institute, Baltimore, MD.
Emily MyersDepartment of Health Care Sciences, Wayne State University, Detroit, MI.
Peter A CalabresiDepartment of Neurology, Johns Hopkins University, Baltimore, MD; Department of Neuroscience, Johns Hopkins University, Baltimore, MD.
Kathleen M ZackowskiCenter for Movement Studies, Kennedy Krieger Institute, Baltimore, MD; Physical Medicine and Rehabilitation, Johns Hopkins School of Medicine, Baltimore, MD; Department of Neurology, Johns Hopkins University, Baltimore, MD.
Johns Hopkins University · USKennedy Krieger Institute · USWayne State University · USBeijing Institute of Technology · CNTulane University · US

Funding

Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
OCT and OCTA image processing for retinal assessment of people with MSR01EY032284 · NEI · JOHNS HOPKINS UNIVERSITY · PI PRINCE, JERRY L · 2021 to 2024
$1.8M
NEI NIH HHS R01 EY032284NINDS NIH HHS R01 NS082347
6 · The paper itself

Abstract

objectiveTo evaluate relationships between specific cerebellar regions and common clinical measures of motor and cognitive function in persons with multiple sclerosis (PwMS).

designCross-sectional.

settingLaboratory.

participantsTwenty-nine PwMS and 28 age- and sex-matched controls without multiple sclerosis (MS) (N=57).

interventionsNot applicable.

main outcome measuresBoth diffusion and lobule magnetic resonance imaging analyses and common clinical measures of motor and cognitive function were used to examine structure-function relationships in the cerebellum.

resultsPwMS demonstrate significantly worse motor and cognitive function than controls, including weaker strength, slower walking, and poorer performance on the Symbol Digit Modalities Test, but demonstrate no differences in cerebellar volume. However, PwMS demonstrate significantly worse diffusivity (mean diffusivity: P=.0003; axial diffusivity: P=.0015; radial diffusivity: P=.0005; fractional anisotropy: P=.016) of the superior cerebellar peduncle, the primary output of the cerebellum. Increased volume of the motor lobules (I-V, VIII) was significantly related to better motor (P<.022) and cognitive (P=.046) performance, and increased volume of the cognitive lobules (VI-VII) was also related to better motor (P<.032) and cognitive (P=.008) performance, supporting the role of the cerebellum in both motor and cognitive functioning.

conclusionsThese data highlight the contributions of the cerebellum to both motor and cognitive function in PwMS. Using novel neuroimaging techniques to examine structure-function relationships in PwMS improves our understanding of individualized differences in this heterogeneous group and may provide an avenue for targeted, individualized rehabilitation aimed at improving cerebellar dysfunction in MS.

Indexed as

Multiple SclerosisCerebellumCognitionCross-Sectional StudiesHumansMagnetic Resonance ImagingCerebellumCognitionDiffusion tensor imagingMagnetic resonance imagingMultiple sclerosisRehabilitation

Identifiers

PMID34998712
PMCPMC12494151
OpenAlexW4206705039

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.