Evidence map›Paper›PMID 34998697›Full record

ArticleSurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery2022

Fatty acid binding protein 4 regulates pancreatic cancer cell proliferation via activation of nuclear factor E2-related factor 2.

Keith Wirth, Shuhei Shinoda, Mizuho Sato-Dahlman, Deborah M Dickey, David A Bernlohr, Sayeed Ikramuddin, Masato Yamamoto

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Keith WirthDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota.
Shuhei ShinodaDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota.
Mizuho Sato-DahlmanDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Deborah M DickeyDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
David A BernlohrDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota.
Sayeed IkramuddinDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota.
Masato YamamotoDepartment of Surgery, University of Minnesota, Minneapolis, Minnesota; Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota. Electronic address: yamam016@umn.edu.
University of Minnesota · US

Funding

LIPID BINDING PROTEINS IN OBESITY/DIABETES SYNDROMESR01DK053189 · NIDDK · UNIVERSITY OF MINNESOTA TWIN CITIES · PI BERNLOHR, DAVID A · 1998 to 2020
$5.6M
Training the Next Generation of Surgeon-Scientists in PancreatologyT32DK108733 · NIDDK · UNIVERSITY OF MINNESOTA · PI Srinath Chinnakotla, MASATO YAMAMOTO · 2017 to 2026
$1.4M
Vertical Sleeve Gastrectomy for Treatment of NASH: a pilot randomized controlR01DK128325 · NIDDK · UNIVERSITY OF MINNESOTA · PI HAMEED, BILAL, IKRAMUDDIN, SAYEED · 2021 to 2023
$947k
Hepatic Energy Fluxes, NASH, and Vertical Sleeve GastrectomyR21DK122832 · NIDDK · UNIVERSITY OF MINNESOTA · PI CRAWFORD, PETER A, IKRAMUDDIN, SAYEED · 2019 to 2020
$424k
Lipid Binding Proteins in Obesity and Diabetes SyndromesR56DK053189 · NIDDK · UNIVERSITY OF MINNESOTA · PI BERNLOHR, DAVID A · 2011 to 2017
$300k
NIDDK NIH HHS R01 DK053189NIDDK NIH HHS R01 DK128325NIDDK NIH HHS R21 DK122832NIDDK NIH HHS R56 DK053189NIDDK NIH HHS T32 DK108733
6 · The paper itself

Abstract

backgroundObesity and diabetes are associated with an increased incidence of pancreatic cancer. Fatty acid binding protein 4 (FABP4), noted to be higher in patients with severe obesity, is linked to the development and progression of several cancers, and its level in the circulation decreases after bariatric surgery.

objectiveIn this paper, we evaluate the role of FABP4 in pancreatic cancer progression.

settingUniversity Hospital and Laboratories, United States. METHODS AND

resultsWhen Panc-1 (human) and Pan02 (mouse) pancreatic cancer cells were treated with FABP4 or the-single-point mutant FABP4 (R126Q, fatty acid binding site mutant), only FABP4 stimulated cellular proliferation. The transcriptional activity of nuclear factor E2-related factor 2 (NRF2) was increased in response to FABP4 but not the R126Q. FABP4 treatment also led to downregulation of reactive oxygen species (ROS) activity. Consistent with induced cell propagation by FABP4, the growth of Pan02 tumor was decreased in FABP4-null animals compared with C57BL/6J controls.

conclusionThese results suggest that FABP4 increases pancreatic cancer proliferation via activation of NRF2 and downregulation of ROS activity.

Indexed as

NF-E2-Related Factor 2Pancreatic NeoplasmsAnimalsCell ProliferationFatty Acid-Binding ProteinsHumansMiceMice, Inbred C57BLFABP4 protein, humanFatty Acid-Binding ProteinsNF-E2-Related Factor 2Cell proliferationFABP4Fatty acid binding protein 4NRF2Pancreatic cancer

Identifiers

PMID34998697
PMCPMC8960336
OpenAlexW4200265131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.