ArticleCurrent biology : CB2022
Unique spatiotemporal fMRI dynamics in the awake mouse brain.
Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 1 of them a synthesis that pooled it.
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Who cites it
85 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Where do we stand on fMRI in awake mice?Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- SORDINO: silent, sensitive, specific and artifact-resistant fMRI in awake, behaving mice.Nature neuroscience · 2026Article
- Arousal-driven critical roaming reproduces human functional connectivity dynamics.PLoS biology · 2026Article
- Brain-Wide Activations Related to Forepaw Force Control Identified by Behaving Mouse FMRI.eNeuro · 2026Article
- Spatiotemporal brain-state dynamics delineate executive function subtypes in school-aged autism: evidence from co-activation patterns and a four-year follow-up.Molecular autism · 2026Article
- Behavior Differentially Shapes Spontaneous Cortical Network Dynamics Across Frequencies.bioRxiv : the preprint server for biology · 2026Article
- Resting fMRI functional connectivity reflects fluctuations in inhibitory interneuron activity.bioRxiv : the preprint server for biology · 2026Article
- Functional Ultrasound Localization Microscopy on Freely Moving Rats.Research square · 2026Article
- Dissociable, species-specific impact of Aβ on static and dynamic functional connectomes.bioRxiv : the preprint server for biology · 2026Article
- UltraFast Layer-Resolved Encoding (uFLARE) functional MRI deciphers bidirectional signaling from spontaneous activity.Nature communications · 2026Article
- Convergent transcriptomic and connectomic controllers of information integration and its anaesthetic breakdown across mammalian brains.Nature human behaviour · 2026Article
- Competitive interactions shape mammalian brain network dynamics and computation.Nature neuroscience · 2026Article
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Connectomic and behavioural alterations in creatine transporter deficiency are partially normalized by gene therapy.Brain : a journal of neurology · 2026Article
- Unraveling spatiotemporal dynamics in transdiagnosis subtypes of major depressive disorder and bipolar disorder: insights from co-activation patterns and treatment response.Molecular psychiatry · 2026Article
- Open-Source Platform for Adjustable Training Regimes in Freely Moving and Head-Fixed Mice.eNeuro · 2026Article
- Biophysical mechanisms of default mode network function and dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Article
- Attractor dynamics of a whole-cortex network model predicts emergence and structure of fMRI co-activation patterns in the mouse brain.PLoS computational biology · 2026Article
- Synapse types are spatially associated with regional hemodynamics in the mouse brain.PLoS biology · 2026Article
25 more citing papers are in PubMed but not listed here.
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10 authors.
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Abstract
Human imaging studies have shown that spontaneous brain activity exhibits stereotypic spatiotemporal reorganization in awake, conscious conditions with respect to minimally conscious states. However, whether and how this phenomenon can be generalized to lower mammalian species remains unclear. Leveraging a robust protocol for resting-state fMRI (rsfMRI) mapping in non-anesthetized, head-fixed mice, we investigated functional network topography and dynamic structure of spontaneous brain activity in wakeful animals. We found that rsfMRI networks in the awake state, while anatomically comparable to those observed under anesthesia, are topologically configured to maximize interregional communication, departing from the underlying community structure of the mouse axonal connectome. We further report that rsfMRI activity in wakeful animals exhibits unique spatiotemporal dynamics characterized by a state-dependent, dominant occurrence of coactivation patterns encompassing a prominent participation of arousal-related forebrain nuclei and functional anti-coordination between visual-auditory and polymodal cortical areas. We finally show that rsfMRI dynamics in awake mice exhibits a stereotypical temporal structure, in which state-dominant coactivation patterns are configured as network attractors. These findings suggest that spontaneous brain activity in awake mice is critically shaped by state-specific involvement of basal forebrain arousal systems and document that its dynamic structure recapitulates distinctive, evolutionarily relevant principles that are predictive of conscious states in higher mammalian species.
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