ArticleCerebral cortex (New York, N.Y. : 1991)2022
Brain network segregation and integration during painful thermal stimulation.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- netneurotools: a trainee-oriented approach to network neuroscience.Nature protocols · 2026Review
- Nonsuicidal self-injury prediction with pain-processing neural circuits using interpretable graph neural network.Annals of medicine · 2025Article
- Brain network hypersensitivity underlies pain crises in sickle cell disease.Scientific reports · 2024Article
- Dynamic segregation and integration of brain functional networks associated with emotional arousal.iScience · 2023Article
- The Role of the Skin in Interoception: A Neglected Organ?Perspectives on psychological science : a journal of the Association for Psychological Science · 2023Article
- Brain system segregation and pain catastrophizing in chronic pain progression.Frontiers in neuroscience · 2023Article
- Multiple spatial scale mapping of time-resolved brain network reconfiguration during evoked pain in patients with rheumatoid arthritis.Frontiers in neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to determine changes in brain network integration/segregation during thermal pain using methods optimized for network connectivity events with high temporal resolution. Participants (n = 33) actively judged whether thermal stimuli applied to the volar forearm were painful or not and then rated the warmth/pain intensity after each trial. We show that the temporal evolution of integration/segregation within trials correlates with the subjective ratings of pain. Specifically, the brain shifts from a segregated state to an integrated state when processing painful stimuli. The association with subjective pain ratings occurred at different time points for all networks. However, the degree of association between ratings and integration/segregation vanished for several brain networks when time-varying functional connectivity was measured at lower temporal resolution. Moreover, the increased integration associated with pain is explained to some degree by relative increases in between-network connectivity. Our results highlight the importance of investigating the relationship between pain and brain network connectivity at a single time point scale, since commonly used temporal aggregations of connectivity data may result in that fine-scale changes in network connectivity may go unnoticed. The interplay between integration/segregation reflects shifting demands of information processing between brain networks and this adaptation occurs both for cognitive tasks and nociceptive processing.
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