ArticleInfection2022
Comparison of fatigue, cognitive dysfunction and psychological disorders in post-COVID patients and patients after sepsis: is there a specific constellation?
Article in Infection, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 3 of them syntheses that pooled it.
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Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Prevalence and long-term outcomes of brain fog and cognitive impairment in individuals with long COVID: A systematic review.Medicine · 2026Pooled it
- Long-term neurological and cognitive impact of COVID-19: a systematic review and meta-analysis in over 4 million patients.BMC neurology · 2025Pooled it
- Pooled it
- Cognitive Health and Quality of Life After Surviving Sepsis: A Narrative Review.Journal of intensive care medicine · 2026Review
- Trajectories of sepsis survivors in Australia: A scoping review.Journal of the Intensive Care Society · 2026Article
- Article
- Lessons from irritable bowel syndrome: potential for understanding and managing post-COVID.Frontiers in immunology · 2026Review
- A randomised, placebo-controlled, triple-blind clinical trial to investigate the efficacy ofFrontiers in human neuroscience · 2026Article
- Possible link between steatotic liver diseases, severe COVID-19 and cognitive impairment in post-COVID-19 syndrome.Infection · 2025Article
- A multidisciplinary review of long COVID to address the challenges in diagnosis and updated management guidelines.Annals of medicine and surgery (2012) · 2025Review
- Be-SNAP: the Belgian Sepsis National Action Plan.Frontiers in public health · 2025Article
- Defining and measuring long COVID fatigue: a scoping review.BMJ open · 2024Article
- Longterm course of neuropsychological symptoms and ME/CFS after SARS-CoV-2-infection: a prospective registry study.European archives of psychiatry and clinical neuroscience · 2024Article
- Substantial differences in perception of disease severity between post COVID-19 patients, internists, and psychiatrists or psychologists: the Health Perception Gap and its clinical implications.European archives of psychiatry and clinical neuroscience · 2024Article
- Characterization of cognitive symptoms in post COVID-19 patients.European archives of psychiatry and clinical neuroscience · 2024Article
- Cognitive Symptoms of Post-COVID-19 Condition and Daily Functioning.JAMA network open · 2024Article
- Persistent neurocognitive deficits in cognitively impaired survivors of sepsis are explained by reductions in working memory capacity.Frontiers in psychology · 2024Article
- Persistent cognitive slowing in post-COVID patients: longitudinal study over 6 months.Journal of neurology · 2024Article
- Brain Health After COVID-19, Pneumonia, Myocardial Infarction, or Critical Illness.JAMA network open · 2023Article
- [Cognitive alterations in patients recovered from COVID-19 treated in Cardiopulmonary Rehabilitation].Revista medica del Instituto Mexicano del Seguro Social · 2023Observational
Corrections and comments
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSequelae of COVID-19 can be severe and longlasting. We compared frequencies of fatigue, depression and cognitive dysfunction in survivors of SARS-CoV-2-infection and sepsis.
methodsWe performed a prospective cohort study of 355 symptomatic post-COVID patients who visited our out-patient clinic for post-COVID-19 care. We compared them with 272 symptomatic patients from the Mid-German Sepsis Cohort, which investigates the long-term courses of sepsis survivors. Possible predictors for frequent clinical findings (fatigue, signs of depression, cognitive dysfunction) in post-COVID were investigated with multivariable logistic regression.
resultsMedian age of the post-COVID patients was 51 years (range 17-86), 60.0% were female, and 31.8% required hospitalization during acute COVID-19. In the post-COVID patients (median follow-up time: 163 days) and the post-sepsis patients (180 days), fatigue was found in 93.2% and 67.8%, signs of depression were found in 81.3% and 10.9%, and cognitive dysfunction was found in 23.5% and 21.3%, respectively. In post-COVID, we did not observe an association between fatigue or depression and the severity of acute COVID-19. In contrast, cognitive dysfunction was associated with hospitalization (out-patient versus in-patient) and more frequent in post-COVID patients treated on an ICU compared to the MSC patients.
conclusionIn post-COVID patients, fatigue and signs of depression are more common than in sepsis survivors, independent from the acute SARS-CoV-2-infection. In contrast, cognitive dysfunction is associated with hospitalization. Despite the differences in frequencies, owing to the similarity of post-COVID and post-sepsis sequelae, this knowledge may help in implementing follow-up approaches after SARS-CoV-2 infection.
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