Evidence map›Paper›PMID 34997475›Full record

ReviewClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2022

A strategic reflection for the management and implementation of CAR-T therapy in Spain: an expert consensus paper.

N Zozaya, J Villaseca, F Abdalla, M A Calleja, J L Díez-Martín, J Estévez, R García-Sanz, J Martínez-López, J Sierra, R Vera and 1 more

Open access · hybridAbstract readReviewConsensus Statement
In one paragraph

Review in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

N ZozayaHealth Economics Department, Weber Economía y Salud, C/Moreto 17, 5D, 28014, Madrid, Spain. neboa.zozaya@weber.org.es.ORCID http://orcid.org/0000-0003-4618-6894
J VillasecaHealth Economics Department, Weber Economía y Salud, C/Moreto 17, 5D, 28014, Madrid, Spain.ORCID http://orcid.org/0000-0003-4292-7683
F AbdallaHealth Economics Department, Weber Economía y Salud, C/Moreto 17, 5D, 28014, Madrid, Spain.ORCID http://orcid.org/0000-0003-2276-6202
M A CallejaPharmacy Department, Hospital Universitario Virgen Macarena, Seville, Spain.ORCID http://orcid.org/0000-0001-8449-5490
J L Díez-MartínHematology Department, Hospital GU Gregorio Marañón, Gregorio Marañón Health Research Institute, Madrid, Spain.ORCID http://orcid.org/0000-0003-1869-0129
J EstévezThe Spanish Society of Health Executives, Sociedad Española de Directivos de La Salud (SEDISA), Madrid, Spain.
R García-SanzHematology Service, CIBERONC, and Salamanca Cancer Research Centre-IBMCC (USAL-CSIC), University Hospital of Salamanca (HUS/IBSAL), Salamanca, Spain.ORCID http://orcid.org/0000-0003-4120-2787
J Martínez-LópezHematology Department, Hospital Universitario, 12 de Octubre, Complutense University of Madrid, CNIO, CIBERONC, Madrid, Spain.ORCID http://orcid.org/0000-0001-7908-0063
J SierraHematology Department and Sant Pau Biomedical Research Institute (IIB-SP), Hospital de la Santa Creu i Sant Pau, Univarsitat Autonoma of Barcelona, Barcelona, Spain.
R VeraMedical Oncology Service, Navarra Hospital Complex, Navarra Hospital, Pamplona, Navarra, Spain.ORCID http://orcid.org/0000-0003-1524-3147
A Hidalgo-VegaWeber Foundation, Madrid, Spain.ORCID http://orcid.org/0000-0003-1031-2051
Weber · ESUniversidad Complutense de Madrid · ESHospital de Sant Pau · ESHospital Universitario Virgen Macarena · ESInstituto de Investigación Biomédica de Salamanca · ESUniversidad de Las Palmas de Gran Canaria · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CAR-T cell therapy represents a therapeutic revolution in the prognosis and treatment of patients with certain types of hematological cancer. However, they also pose new challenges in the healthcare, regulatory and financial fields. The aim of the RET-A project was to undertake a strategic reflection on the management of CAR-T therapies within the Spanish National Health System, to agree on recommendations that will help to better deal with the new context introduced by these cell therapies in the present and in the future. This think tank involved 40 key agents and opinion leaders. The experts identified three great challenges for implementing advanced therapies in Spain: therapeutic individualisation, with a multidisciplinary approach; acceleration of access times, by minimizing bureaucracy; and increase in the number of centers qualified to manage the CAR-T therapies in the NHS. The experts agreed on the ideal criteria for designating those qualified centers. They also agreed on a comprehensive CAR-T care pathway with the timings and roles which would ideally be involved in each part of the process.

Indexed as

Hematologic NeoplasmsReceptors, Chimeric AntigenConsensusHumansImmunotherapy, AdoptiveSpainReceptors, Chimeric AntigenAdvanced therapiesCAR-T therapyNational health systemSpain

Identifiers

PMID34997475
PMCPMC8741571
OpenAlexW4205621817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.