Evidence map›Paper›PMID 34997466›Full record

ArticleJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2022

Risk Nomogram Does Not Predict Anastomotic Leakage After Colon Surgery Accurately: Results of the Multi-center LekCheck Study.

Izel Ozmen, Vera E M Grupa, Sergei Bedrikovetski, Nagendra N Dudi-Venkata, Daitlin E Huisman, Muriël Reudink, Gerrit D Slooter, Tarik Sammour, Hidde M Kroon, Freek Daams and 1 more

Open access · bronzeAbstract read
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In one paragraph

Article in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Izel OzmenColorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-1014-7175
Vera E M GrupaColorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-8815-2767
Sergei BedrikovetskiColorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0001-9330-625X
Nagendra N Dudi-VenkataColorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-9775-3599
Daitlin E HuismanDepartment of Surgery, VU Medical Center Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0003-3001-000X
Muriël ReudinkDepartment of Surgery, Máxima Medical Center Veldhoven, Veldhoven, the Netherlands.ORCID http://orcid.org/0000-0002-4349-7948
Gerrit D SlooterDepartment of Surgery, Máxima Medical Center Veldhoven, Veldhoven, the Netherlands.ORCID http://orcid.org/0000-0001-6910-9512
Tarik SammourColorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia.ORCID http://orcid.org/0000-0002-4918-8871
Hidde M KroonColorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, South Australia, Australia. Hidde.Kroon@sa.gov.au.ORCID http://orcid.org/0000-0002-8923-7527
Freek DaamsDepartment of Surgery, VU Medical Center Amsterdam, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-6323-6342
LekCheck Study Group
Royal Adelaide Hospital · AUAmsterdam UMC Location Vrije Universiteit Amsterdam · NLRadboud University Nijmegen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAnastomotic leakage (AL) is a dreaded complication after colorectal surgery. Preoperatively identifying high-risk patients can help to reduce the incidence of this complication. For this reason, AL risk nomograms have been developed. The objective of this study was to test the AL risk nomogram developed by Frasson, et al. for validity and to identify risk-factors for AL.

methodsFrom the international multi-center LekCheck study database, patients who underwent colonic surgery with the formation of an anastomosis were included. Data were prospectively collected between 2016 and 2019 at 14 hospitals. Univariate and multivariable regression analyses, and area under receiver operating characteristic curve analysis (AUROC) were performed.

resultsA total of 643 patients were included. The median age was 70 years and 51% were male. The majority underwent surgery for malignancies (80.7%). The overall AL rate was 9.2%. The risk nomogram was not predictive for AL in the population tested (AUROC 0.572). Low preoperative haemoglobin (p = 0.006), intraoperative hypothermia (p = 0.02), contamination of the operative field (p = 0.004), and use of epidural analgesia (p = 0.02) were independent risk-factors for AL.

conclusionThe AL risk nomogram could not be validated using the international LekCheck study database. In the future, intraoperative predictive factors for AL, as identified in this study, should also be included in AL risk predictors.

Indexed as

Digestive System Surgical ProceduresNomogramsAgedAnastomotic LeakColonFemaleHumansMaleRetrospective StudiesRisk FactorsAnastomotic leakageColon cancerColonic surgeryRisk score validation

Identifiers

PMID34997466
OpenAlexW4205977020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.