Evidence map›Paper›PMID 34997457›Full record

ArticleNeurotoxicity research2022

Involvement of FoxO1, Sp1, and Nrf2 in Upregulation of Negative Regulator of ROS by 15d-PGJ

Chen-Yu Wang, Chien-Chung Yang, Li-Der Hsiao, Chuen-Mao Yang

Open access · hybridAbstract read
In one paragraph

Article in Neurotoxicity research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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  3. Rubicon modulates neuroimmune responses following traumatic brain injury.bioRxiv : the preprint server for biology · 2026
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  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Chen-Yu Wang *Department of Pharmacology, College of Medicine, China Medical University, Taichung, 40402, Taiwan.
Chien-Chung Yang *Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital At Tao-Yuan, Kwei-San, Tao-Yuan, 33302, Taiwan.
Li-Der HsiaoDepartment of Pharmacology, College of Medicine, China Medical University, Taichung, 40402, Taiwan.
Chuen-Mao YangDepartment of Pharmacology, College of Medicine, China Medical University, Taichung, 40402, Taiwan. chuenmao@mail.cmu.edu.tw.ORCID http://orcid.org/0000-0002-3208-5438
Asia University · TWChina Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Excessive production of reactive oxygen species (ROS) by NADPH oxidase (Nox) resulted in inflammation. The negative regulator of ROS (NRROS) dampens ROS generation during inflammatory responses. 15-Deoxy-∆12,14-prostaglandin J

Indexed as

AstrocytesNF-E2-Related Factor 2AnimalsBrainForkhead Box Protein O1Hydrogen PeroxideInterleukin-6Nerve Tissue ProteinsPhosphatidylinositol 3-KinasesProstaglandin D2RatsReactive Oxygen SpeciesUp-RegulationForkhead Box Protein O1Foxo1 protein, ratHydrogen PeroxideInterleukin-6Nerve Tissue ProteinsNF-E2-Related Factor 2Phosphatidylinositol 3-KinasesProstaglandin D2Reactive Oxygen Species15d-PGJ2Hydrogen peroxideIL-6NADPH oxidaseNRROSp47phox

Identifiers

PMID34997457
PMCPMC8784370
OpenAlexW4205172264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.