ArticleEuropean journal of nuclear medicine and molecular imaging2022
Differential associations between neocortical tau pathology and blood flow with cognitive deficits in early-onset vs late-onset Alzheimer's disease.
Article in European journal of nuclear medicine and molecular imaging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- [European journal of nuclear medicine and molecular imaging · 2026Article
- Regional cerebral hypometabolism and pathological heterogeneity in sporadic early onset alzheimer's disease: China Aging and Neurodegenerative Initiative (CANDI) study.European journal of nuclear medicine and molecular imaging · 2026Article
- Bayesian modelling demonstrates clinically relevant heterogeneity in Tau PET patterns in Alzheimer's disease.European journal of nuclear medicine and molecular imaging · 2026Article
- Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimer's disease.medRxiv : the preprint server for health sciences · 2026Article
- Early-phaseEuropean journal of nuclear medicine and molecular imaging · 2025Article
- Characterizing visual read tau-PET-negative participants with Alzheimer's disease dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Medial temporal lobe atrophy patterns in early-versus late-onset amnestic Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- Beyond amyloid and tau: rethinking Alzheimer's disease through less explored avenues.Open biology · 2024Review
- Medial temporal lobe atrophy patterns in early- versus late-onset amnestic Alzheimer's disease.bioRxiv : the preprint server for biology · 2024Article
- Interactions between vascular burden and amyloid-β pathology on trajectories of tau accumulation.Brain : a journal of neurology · 2024Article
- Investigating the structural network underlying brain-immune interactions using combined histopathology and neuroimaging: a critical review for its relevance in acute and long COVID-19.Frontiers in psychiatry · 2024Review
- A review of the flortaucipir literature for positron emission tomography imaging of tau neurofibrillary tangles.Brain communications · 2024Review
- Genetically identical twin-pair difference models support the amyloid cascade hypothesis.Brain : a journal of neurology · 2023Article
- Tau as a biomarker of cognitive impairment and neuropsychiatric symptom in Alzheimer's disease.Human brain mapping · 2023Article
- Divergent effects of age on imaging-based ATN biomarkers and cognition in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeEarly-onset Alzheimer's disease (EOAD) and late-onset Alzheimer's disease (LOAD) differ in neuropathological burden and type of cognitive deficits. Assessing tau pathology and relative cerebral blood flow (rCBF) measured with [
methodsSeventy-nine amyloid-positive individuals with a clinical diagnosis of AD (EOAD: n = 35, age-at-PET = 59 ± 5, MMSE = 23 ± 4; LOAD: n = 44, age-at-PET = 71 ± 5, MMSE = 23 ± 4) underwent a 130-min dynamic [
resultsBoth region-of-interest and voxel-wise contrasts showed higher [
conclusionsCompared to LOAD, the degree of lateral temporal and occipitoparietal tau pathology and relative cerebral blood-flow is more strongly associated with cognition in EOAD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.