Evidence map›Paper›PMID 34997267›Full record

ArticleEuropean journal of nutrition2022

The effect of oral iron supplementation on the gut microbiota, gut inflammation, and iron status in iron-depleted South African school-age children with virally suppressed HIV and without HIV.

Charlene Goosen, Sebastian Proost, Raul Y Tito, Jeannine Baumgartner, Shaun L Barnabas, Mark F Cotton, Michael B Zimmermann, Jeroen Raes, Renée Blaauw

Registry-linked trialOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in European journal of nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03572010 (A Novel Stable Iron Isotope Method to Define Iron Needs and Improve Iron Nutrition in HIV+ and HIV- Children), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03572010 nacompletednot on this map

A Novel Stable Iron Isotope Method to Define Iron Needs and Improve Iron Nutrition in HIV+ and HIV- Children

TypeinterventionalSponsorSwiss Federal Institute of TechnologyRan2018 to 2020Enrolled180ConditionsIron-deficiencyArmsFeFum fortified maize test meal, FeSO4 fortified LNS, FeSO4 supplement, FeSO4 fortified fruit juice
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Charlene Goosen *Division of Human Nutrition, Department of Global Health, Stellenbosch University, Cape Town, South Africa. charleneg@sun.ac.za.ORCID http://orcid.org/0000-0003-0082-3085
Sebastian Proost *Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0002-6792-9442
Raul Y TitoLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium.ORCID http://orcid.org/0000-0001-9660-7621
Jeannine BaumgartnerLaboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.ORCID http://orcid.org/0000-0002-9107-4181
Shaun L BarnabasFamily Centre for Research With Ubuntu, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0002-4819-9501
Mark F CottonFamily Centre for Research With Ubuntu, Department of Paediatrics and Child Health, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0003-2559-6034
Michael B ZimmermannLaboratory of Human Nutrition, Department of Health Sciences and Technology, ETH Zurich, Zurich, Switzerland.
Jeroen RaesLaboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium. jeroen.raes@kuleuven.be.ORCID http://orcid.org/0000-0002-1337-041X
Renée BlaauwDivision of Human Nutrition, Department of Global Health, Stellenbosch University, Cape Town, South Africa.ORCID http://orcid.org/0000-0001-7413-5918
Rega Institute for Medical Research · BEStellenbosch University · ZAETH Zurich · CHUniversity of Cape Town · ZA

Funding

Ernst and Ethel Eriksen Trust BursaryFondation L'Oréal L'Oréal-UNESCO For Women in Science Sub-Saharan Africa FellowshipSouth African Medical Research Council Bongani Mayosi National Health Scholars ProgrammeThrasher Research Fund 14199
6 · The paper itself

Abstract

purposeBoth HIV and oral iron interventions may alter gut microbiota composition and increase gut inflammation. We determined the effect of oral iron supplementation on gut microbiota composition, gut inflammation, and iron status in iron-depleted South Africa school-aged children living with HIV (HIV+) but virally suppressed on antiretroviral therapy and children without HIV (HIV-ve).

methodsIn this before-after intervention study with case-control comparisons, we provided 55 mg elemental iron from ferrous sulphate, once daily for 3 months, to 33 virally suppressed (< 50 HIV RNA copies/mL) HIV+ and 31 HIV-ve children. At baseline and endpoint, we assessed microbial composition of faecal samples (16S rRNA sequencing), and markers of gut inflammation (faecal calprotectin), anaemia (haemoglobin) and iron status (plasma ferritin, soluble transferrin receptor). This study was nested within a larger trial registered at clinicaltrials.gov as NCT03572010.

resultsHIV+ (11.3y SD ± 1.8, 46% male) and HIV-ve (11.1y SD ± 1.7, 52% male) groups did not significantly differ in age or sex ratio. Following iron supplementation, improvements were observed in haemoglobin (HIV+ : 118 to 124 g/L, P = 0.003; HIV-ve: 120 to 124 g/L, P = 0.003), plasma ferritin (HIV+ : 15 to 34 µg/L, P < 0.001; HIV-ve: 18 to 37 µg/L, P < 0.001), and soluble transferrin receptor (HIV+ : 7.1 to 5.9 mg/L, P < 0.001; HIV-ve: 6.6 to 5.7 mg/L, P < 0.001), with no significant change in the relative abundance of any genera, alpha diversity of the gut microbiota (HIV+ : P = 0.37; HIV-ve: P = 0.77), or faecal calprotectin (HIV+ : P = 0.42; HIV-ve: P = 0.80).

conclusionOur findings suggest that oral iron supplementation can significantly improve haemoglobin and iron status without increasing pathogenic gut microbial taxa or gut inflammation in iron-depleted virally suppressed HIV+ and HIV-ve school-age children.

Indexed as

Anemia, Iron-DeficiencyGastrointestinal MicrobiomeHIV InfectionsChildDietary SupplementsFemaleFerritinsHemoglobinsHumansInflammationIronLeukocyte L1 Antigen ComplexMaleReceptors, TransferrinRNA, Ribosomal, 16SSouth AfricaFerritinsHemoglobinsIronLeukocyte L1 Antigen ComplexReceptors, TransferrinRNA, Ribosomal, 16SGut inflammationGut microbiotaHIVIron deficiencyIron interventionSchool-age children

Identifiers

PMID34997267
OpenAlexW4205807722

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.