Evidence map›Paper›PMID 34997223›Full record

ReviewPediatric research2024

Oxygen saturation and heart rate in healthy term and late preterm infants with delayed cord clamping.

Inmaculada Lara-Cantón, Shiraz Badurdeen, Janneke Dekker, Peter Davis, Calum Roberts, Arjan Te Pas, Máximo Vento

Abstract readReview
In one paragraph

Review in Pediatric research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Review
  9. Article
  10. How Delayed Cord Clamping Saves Newborn Lives.Children (Basel, Switzerland) · 2025
    Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Inmaculada Lara-CantónNeonatal Research Group, Health Research Institute and University and Polytechnic Hospital La Fe, Valencia, Spain.
Shiraz BadurdeenNewborn Research Center and Neonatal Services, The Royal Women´s Hospital, Melbourne, VIC, Australia.
Janneke DekkerDivision of Neonatology, Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands.
Peter DavisNewborn Research Center and Neonatal Services, The Royal Women´s Hospital, Melbourne, VIC, Australia.
Calum RobertsDepartment of Paediatrics, Monash University, Clayton, VIC, Australia.
Arjan Te PasDivision of Neonatology, Department of Paediatrics, Leiden University Medical Centre, Leiden, The Netherlands.
Máximo VentoNeonatal Research Group, Health Research Institute and University and Polytechnic Hospital La Fe, Valencia, Spain. maximo.vento@uv.es.

Funding

European Regional Development Fund (FEDER)Instituto Carlos III (Spanish Ministry of Science and Innovation)ISCIII- Sub-Directorate General for Research Assessment and Promotion
6 · The paper itself

Abstract

Blood oxygen in the fetus is substantially lower than in the newborn infant. In the minutes after birth, arterial oxygen saturation rises from around 50-60% to 90-95%. Initial respiratory efforts generate negative trans-thoracic pressures that drive liquid from the airways into the lung interstitium facilitating lung aeration, blood oxygenation, and pulmonary artery vasodilatation. Consequently, intra- (foramen ovale) and extra-cardiac (ductus arteriosus) shunting changes and the sequential circulation switches to a parallel pulmonary and systemic circulation. Delaying cord clamping preserves blood flow through the ascending vena cava, thus increasing right and left ventricular preload. Recently published reference ranges have suggested that delayed cord clamping positively influenced the fetal-to-neonatal transition. Oxygen saturation in babies with delayed cord clamping plateaus significantly earlier to values of 85-90% than in babies with immediate cord clamping. Delayed cord clamping may also contribute to fewer episodes of brady-or-tachycardia in the first minutes after birth, but data from randomized trials are awaited. IMPACT: Delaying cord clamping during fetal to neonatal transition contributes to a significantly earlier plateauing of oxygen saturation and fewer episodes of brady-and/or-tachycardia in the first minutes after birth. We provide updated information regarding the changes in SpO

Indexed as

Heart RateInfant, PrematureOxygen SaturationFemaleHumansInfant, NewbornOxygenTime FactorsUmbilical CordUmbilical Cord ClampingOxygen

Identifiers

PMID34997223
PMCPMC11499272

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.