ReviewMolecular psychiatry2022
Unconsidered issues of measurement noninvariance in biological psychiatry: A focus on biological phenotypes of psychopathology.
Review in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Beyond DSM Categories: Criteria for Biologically Valid Disease Axes in Psychiatry.Journal of clinical medicine · 2026Review
- Hierarchical Phenotyping of Psychopathology: Implications and Opportunities for Precision Psychiatry When Biology Could Be Associated With Both Symptoms and Syndromes.Biological psychiatry · 2026Review
- The broad structure of psychopathology in the All of Us Research Program.Psychological medicine · 2025Article
- Investigating the impact of lumping heterogenous conduct problems: aggression and rule-breaking rely on distinct spontaneous brain activity.European child & adolescent psychiatry · 2025Article
- Characterizing the hierarchical depression phenotype in sexually diverse individuals.Journal of psychiatric research · 2024Article
- How is inflammation biology truly associated with depression in patients with stable coronary heart disease?: Insights from the heart and Soul study.Brain, behavior, & immunity - health · 2024Article
- Evidence for embracing normative modeling.eLife · 2023Article
- Social Safety Theory: Conceptual foundation, underlying mechanisms, and future directions.Health psychology review · 2023Article
- Psychopathological network for early-onset post-stroke depression symptoms.BMC psychiatry · 2023Article
- Hierarchical Inflammatory Phenotypes of Depression: A Novel Approach Across Five Independent Samples and 27,730 Adults.Biological psychiatry · 2023Article
- Neuroanatomy of post-stroke depression: the association between symptom clusters and lesion location.Brain communications · 2023Article
- Structural disconnection-based prediction of poststroke depression.Translational psychiatry · 2022Article
- Clarifying the causes of consistent and inconsistent findings in genetics.Genetic epidemiology · 2022Review
- Threat vigilance and intrinsic amygdala connectivity.Human brain mapping · 2022Article
- Neural Substrates of Poststroke Depression: Current Opinions and Methodology Trends.Frontiers in neuroscience · 2022Review
- Eye Movement Patterns Can Distinguish Schizophrenia From the Major Affective Disorders and Healthy Control Subjects.Schizophrenia bulletin open · 2022Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
There is increasing appreciation that certain biological processes may not be equally related to all psychiatric symptoms in a given diagnostic category. Research on the biological phenotyping of psychopathology has begun examining the etiological and treatment implications of identified biotypes; however, little attention has been paid to a critical methodological implication of these results: measurement noninvariance. Measurement invariance is the ability of an instrument to measure the same construct, the same way, across different people, or across different time points for the same individual. If what a measure quantifies differs across different people (e.g., those with or without a particular biotype) or time points, then it is invalid to directly compare means on that measure. Using a running example of inflammatory phenotypes of depression, we first describe the biological phenotyping of psychopathology. Second, we discuss three types of measurement invariance. Third, we demonstrate how differential biology-symptom associations invariably creates measurement noninvariance using a theoretical example and simulated data (for which code is provided). We also show how this issue can lead to false conclusions about the broader diagnostic construct. Finally, we provide several suggestions for addressing these important issues to help advance the field of biological psychiatry.
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