Evidence map›Paper›PMID 34997139›Full record

ArticleScientific reports2022

Application of evoked response audiometry for specifying aberrant gamma oscillations in schizophrenia.

Masaya Yanagi, Aki Tsuchiya, Fumiharu Hosomi, Satoshi Ozaki, Osamu Shirakawa

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Masaya YanagiDepartment of Neuropsychiatry, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osaka-sayama, Osaka, 589-8511, Japan. yanagi@med.kindai.ac.jp.
Aki TsuchiyaDepartment of Neuropsychiatry, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osaka-sayama, Osaka, 589-8511, Japan.
Fumiharu HosomiDepartment of Neuropsychiatry, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osaka-sayama, Osaka, 589-8511, Japan.
Satoshi OzakiIzumigaoka Hospital, Izumi, Osaka, Japan.
Osamu ShirakawaDepartment of Neuropsychiatry, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osaka-sayama, Osaka, 589-8511, Japan.
Kindai University · JPIzumi City General Hospital · JP

Funding

Japan Society for the Promotion of Science 16K10229Japan Society for the Promotion of Science 17K10320
6 · The paper itself

Abstract

Gamma oscillations probed using auditory steady-state response (ASSR) are promising clinical biomarkers that may give rise to novel therapeutic interventions for schizophrenia. Optimizing clinical settings for these biomarker-driven interventions will require a quick and easy assessment system for gamma oscillations in psychiatry. ASSR has been used in clinical otolaryngology for evoked response audiometry (ERA) in order to judge hearing loss by focusing on the phase-locked response detectability via an automated analysis system. Herein, a standard ERA system with 40- and 46-Hz ASSRs was applied to evaluate the brain pathophysiology of patients with schizophrenia. Both ASSRs in the ERA system showed excellent detectability regarding the phase-locked response in healthy subjects and sharply captured the deficits of the phase-locked response caused by aberrant gamma oscillations in individuals with schizophrenia. These findings demonstrate the capability of the ERA system to specify patients who have aberrant gamma oscillations. The ERA system may have a potential to serve as a real-world clinical medium for upcoming biomarker-driven therapeutics in psychiatry.

Indexed as

Audiometry, Evoked ResponseEvoked Potentials, AuditoryGamma RhythmAcoustic StimulationAdultAgedBrainCase-Control StudiesFemaleHumansMaleMiddle AgedPredictive Value of TestsSchizophreniaTime FactorsYoung Adult

Identifiers

PMID34997139
PMCPMC8741931
OpenAlexW4206068382

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.